Results 71 to 80 of about 96,889 (339)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Segurança do paciente na administração de medicamento intramuscular em pediatria: avaliação da prática de enfermagem

Revista Gaúcha de Enfermagem, 2018
Resumo OBJETIVOS Avaliar a prática de Enfermagem quanto à administração de medicamento por via intramuscular na pediatria. MÉTODOS Descritivo, observacional, quantitativo, desenvolvido mediante 327 observações da administração de medicamento ...
Thais Lima Vieira De Souza, Rafaela de Oliveira Mota, Eva Anny Wélly de Souza Brito, Laryssa Miranda Vidal Cavalcante Farias, Érica Oliveira Matias, Francisca Elisângela Teixeira Lima   +5 more
doaj   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on BoNT for Androgenetic Alopecia

Dermatology and Therapy
Introduction Recent advancements in androgenetic alopecia (AGA) treatment have highlighted the efficacy of botulinum toxin (BoNT). However, inconsistencies in injection sites and depths warrant attention.
Jiaqi Li, Shu Zhang, Wenbin Zhao, Fengjuan Yang, Maolin Liu, Xiaohua Li, Xian Jiang   +6 more
doaj   +1 more source

Necrotizing Soft Tissue Fasciitis after Intramuscular Injection

Case Reports in Surgery, 2018
Necrotizing soft tissue fasciitis (NSTIs) or necrotizing fasciitis is an infrequent and serious infection. Herein, we describe the clinical course of a female patient who received a diagnosis of NSTIs after gluteus intramuscular injection. We also report
Angelica Abbate, Piero Luigi Almasio, Martina Mongitore, Gaetano Di Vita, Rosalia Patti   +4 more
doaj   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

A Case Report on Gas Gangrene with a Fatal Outcome [PDF]

Journal of Clinical and Diagnostic Research
Gas gangrene, a life-threatening illness caused by Clostridium perfringens, progresses rapidly, resulting in systemic toxicity, multiorgan failure and ultimately death.
Priyadharshini Srinivasan, Vishak Manoj Bhaskar , Nanditha Padikkasu, Pushparani Anand   +3 more
doaj   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Fibrous Myopathy as a Complication of Repeated Intramuscular Injections for Chronic Headache

Pain Research and Management, 2006
Two cases of fibrous myopathy associated with repeated, long-term intramuscular injections for treatment of chronic temporomandibular joint pain and chronic headache, respectively, are described.
R Burnham, S McNeil, C Hegedus, DS Gray
doaj   +1 more source

The Study in Animal Models of Local Action, Acute and Chronic Toxicity of Inactivated Influenza Vaccine Ultriks in Syringe

Эпидемиология и вакцинопрофилактика, 2015
The evaluation of acute and chronic toxicity and local effect of the inactivated influenza vaccine Ultriks in animal models (guinea pigs, mice BALB/c) was performed.
O. G. Kurskaya, K. A. Sharshov, A. Yu. Alekseev, M. A. Gulyaeva, A. M. Shestopalov, L. V. Shestopalova, G. M. Ignatev, V. A. Shkurupiy   +7 more
doaj   +1 more source