Results 181 to 190 of about 1,075,882 (382)

The robotic future of minimally invasive cytoreduction and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies [PDF]

, 2023
Joanna Ortega, Theofano Orfanelli, Edward A. Levine, Ioannis T. Konstantinidis   +3 more
openalex   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

State-of-the-Art Therapy in Peritoneal Carcinomatosis Management

Onco
This paper reviews the surgical management of peritoneal carcinomatosis as new surgical methods have been developed within the past few decades. Traditional methods included cytoreductive surgery with hyperthermic intraperitoneal chemotherapy; however, a
Elbek Fozilov, Anthony Weng, Snigdha Kanadibhotla, Nina D. Kosciuszek, Zhaosheng Jin, Sherif R. Abdel-Misih   +5 more
doaj   +1 more source

Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions : in vitro and in vivo characterization [PDF]

, 2016
Bracke, Marc, Ceelen, Wim, De Clercq, Kaat, De Wever, Olivier, Remon, Jean Paul, Schelfhout, Charlotte, Van Bockstal, Mieke, Vervaet, Chris   +7 more
core   +1 more source

Assessment of clinical benefit and quality of life in patients undergoing cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for management of peritoneal metastases.

, 2013
Yue Zhu, Nader Hanna, Cherif Boutros, H. Richard Alexander   +3 more
openalex   +2 more sources

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control [PDF]

, 2019
Introduction Surgical resection and systemic chemotherapy with temozolomide remain the mainstay for treatment of glioblastoma. However, many patients are not candidates for surgical resection given inaccessible tumor location or poor health status ...
Bernstein, Alexander, Deming, Timothy, Garrett, Matthew, Hung, Derek, Kornblum, Harley, O’Shea, Timothy, Sofroniew, Michael, Soto, Horacio, Staarman, Brittany, Wollenberg, Alexander   +9 more
core  

HARMONIZED STATISTICAL ANALYSIS OF THE EFFICACY OF INTRAPERITONEAL CHEMOTHERAPY REGIMENS WITH DIOXADET ON ASCITIC OVARIAN CANCER MODEL

, 2017
В. Г. Беспалов, А. М. Belyaev, Denis Baranenko, Н. Н. Хромов-Борисов, Valeriy Aleksandrov, Л А Красильникова, Galina S. Kireeva, А. М. Belyaev, Konstantin Senchik, А. Н. Стуков, И. Н. Васильева, А. Л. Семенов, Grigoriy Tochilnikov, Ivan Alvovskiy, Ye. Vyshinskaya   +14 more
openalex   +2 more sources

Mortality and Morbidity after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis [PDF]

, 2013
Akshat Saxena, David L. Morris
openalex   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source