Results 301 to 310 of about 1,006,225 (339)
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Diseases of the Colon & Rectum, 2021
BACKGROUND: Combined treatment modality of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is emerging as an alternative option for colorectal peritoneal metastases, but there is ambiguity regarding patient selection, treatment ...
Manasi Parikh +6 more
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BACKGROUND: Combined treatment modality of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is emerging as an alternative option for colorectal peritoneal metastases, but there is ambiguity regarding patient selection, treatment ...
Manasi Parikh +6 more
semanticscholar +1 more source
Intraperitoneal chemotherapy for ovarian cancer [PDF]
Current Oncology Reports, 2003 Intraperitoneal chemotherapy provides a means by which high concentrations of drugs and long durations of tissue exposure can be attained at the peritoneal surface. It has been studied widely in ovarian cancer, a disease in which intra-abdominal progression remains the major source of morbidity and mortality.
Gini F. Fleming, Gregory Friberg
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Intraperitoneal Chemotherapy with Melphalan
Annals of Internal Medicine, 1984We administered melphalan by the intraperitoneal route to investigate its toxicity and pharmacokinetics. The drug was instilled with 2 litres of fluid and allowed to dwell in the peritoneal cavity for 4 hours. No local toxicity was detected by clinical examination, laboratory tests, or histologic examination.
Stephen B. Howell +2 more
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Pharmacology of Intraperitoneal Chemotherapy
Cancer Investigation, 1983In this review of the pharmacology and clinical application of intraperitoneal drug administration, we have tried to acquaint the reader with the current state of the art. At this juncture it is important to outline briefly some of the major remaining questions.
Charles E. Myers, Jerry M. Collins
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Hyperthermic intraperitoneal chemotherapy (HIPEC) for gynecological cancer
The journal of obstetrics and gynaecology research, 2020Hyperthermic intraperitoneal chemotherapy (HIPEC) is a method of administering anticancer agents directly while heating the abdominal cavity. The aim of this review is to know the current position of HIPEC in ovarian cancer and uterine sarcoma and its ...
H. Tsuyoshi +3 more
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Intraperitoneal chemotherapy for peritoneal metastases: an expert opinion
Expert Opinion on Drug Delivery, 2020Introduction: The rationale for intraperitoneal (IP) drug delivery for patients with peritoneal metastases (PM) is based on the pharmacokinetic advantage resulting from the peritoneal-plasma barrier, and on the potential to adequately treat small, poorly
W. Ceelen +4 more
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Critical Reviews in Oncology/Hematology, 1999
The delivery of antineoplastic agents directly into the peritoneal cavity as treatment of malignancies principally confined to this body compartment (e.g., ovarian cancer) is based on sound pharmacokinetic and anatomic principles. Over the past two decades investigators have defined both the potential benefits, and limitations, associated with this ...
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The delivery of antineoplastic agents directly into the peritoneal cavity as treatment of malignancies principally confined to this body compartment (e.g., ovarian cancer) is based on sound pharmacokinetic and anatomic principles. Over the past two decades investigators have defined both the potential benefits, and limitations, associated with this ...
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Laparoscopical insertion of intraperitoneal catheters for intraperitoneal chemotherapy
Acta Obstetricia et Gynecologica Scandinavica, 2003Background and methods. Eight patients (seven clinically negative stage Ill ovarian cancer and one peritoneal mesothelioma) respectively underwent second‐look laparoscopy for staging, adhesiolysis and insertion of an intraperitoneal catheter and fixation of a portal.
Anaf, Vincent +3 more
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An overview and update of hyperthermic intraperitoneal chemotherapy in ovarian cancer
Expert Opinion on Pharmacotherapy, 2020Introduction: Despite, the strong rationale and evidence of the benefit of postoperative intraperitoneal chemotherapy in advanced ovarian cancer, it has not been widely adopted, mainly due to its high morbidity and logistical difficulties. Intraoperative
E. de Bree, Dimosthenis Michelakis
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Hyperthermic Intraperitoneal Chemotherapy
2017Peritoneal metastasis in abdominal malignancies is associated with a dismal prognosis. In the past, it was considered inoperable and the patient was considered a candidate for palliative chemotherapy alone. The outcome of systemic chemotherapy is poor with the average survival being 6–8 months.
Nikhil Gupta, Shivendra Singh
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