Results 251 to 260 of about 158,913 (343)

Accidental intrathecal methotrexate overdose

Turkish Journal of Hematology, 2011
Emel Özyürek, Namık Özbek
doaj   +1 more source

Effects of methotrexate on Wnt/β‐catenin signaling and glial activation in temporomandibular joint arthritis in rats

European Journal of Oral Sciences, Volume 133, Issue 6, December 2025.
Abstract Rheumatoid arthritis is a chronic autoimmune disease that can affect the temporomandibular joint (TMJ) and cause pain. Methotrexate is widely used to control disease progression, but its effects on pain mechanisms are not fully understood. This study evaluated the antinociceptive effects of methotrexate on pain behavior, Wnt/β‐catenin pathway ...
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Sofia Tavares Bessa, Anamaria Falcão Pereira, Paula Goes, Mariana Lima Vale, Delane Viana Gondim   +6 more
wiley   +1 more source

Efficacy of fentanyl combined with bupivacaine and morphine for spinal anesthesia during cesarean section: A double-blind randomized controlled trial. [PDF]

J Int Med Res
Li G, Zeng F, Qi X, Tan X, Wang H, Huang X, Li Y, Xia Y.   +7 more
europepmc   +1 more source

Intrathecal release of pro- and anti-inflammatory cytokines during stroke

, 1997
E. Tarkowski, Lars Rosengren, Christian Blomstrand, Carsten Wikkelsø, Camilla Steen Jensen, Sven Ekholm, A Tarkowski   +6 more
openalex   +2 more sources

MRI‐based surrogates of brain clearance in narcolepsy type 1

Journal of Sleep Research, Volume 34, Issue 6, December 2025.
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy.
Eva M. van Heese, Jari K. Gool, Gert Jan Lammers, Ysbrand D. van der Werf, Matthias J. P. van Osch, Rolf Fronczek, Lydiane Hirschler   +6 more
wiley   +1 more source

Frontline therapy combining with intrathecal dexamethasone effectively alleviate immune effector cell-associated neurotoxicity syndrome in pediatric relapsed B-ALL receiving pCAR-19B-cases report. [PDF]

BMC Pediatr
Cao L, Zhou M, Wei Z, Zhu R, Chen H, Zhou L, Hu S, Bai Z, Wu S.   +8 more
europepmc   +1 more source

A phase 2 trial of a “sandwich” strategy: Sequential CD22/CD19 chimeric antigen receptor T‐cells therapy combined with autologous hematopoietic stem cell transplantation in patients with Philadelphia chromosome–negative B‐cell acute lymphoblastic leukemia

Cancer, Volume 131, Issue 22, 15 November 2025.
Abstract Background The relapse after chimeric antigen receptor (CAR) T‐cell therapy remains a critical challenge, and the optimal timing and treatment strategies for CAR T urgently need to be explored. Autologous hematopoietic stem cell transplantation (auto‐HSCT) demonstrates comparable leukemia‐free survival (LFS) and overall survival (OS) in ...
Chong‐Sheng Qian, Zi‐Hao Wang, Zheng Li, Zhen Yao, Wen‐Jie Gong, Yan‐Jun Wu, Hai‐Xia Zhou, Ming‐Zhu Xu, Yan Qiu, Shun‐Zhe Xu, Kai‐Wen Tan, Fang‐Tong Liu, Si‐Man Huang, Han‐Yu Cao, Hai‐Ping Dai, De‐Pei Wu, Sheng‐Li Xue   +16 more
wiley   +1 more source

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia. [PDF]

Cancer Epidemiol Biomarkers Prev
Park Y, K C N, Willekens J, Patel C, Savage BA, Lin H, Paneque A, Daly R, Thrope A, Burns MA, Welch JJG, Kahn JM, Kelly KM, Tran TH, Michon B, Gennarini L, Silverman LB, Sands SA, Cole PD.   +18 more
europepmc   +1 more source

A retrospective comparison of intrathecal morphine and epidural hydromorphone for analgesia following posterior spinal fusion in adolescents with idiopathic scoliosis

Paediatric anaesthesia, 2017
Rebecca A. Hong, K. Gibbons, G. Li, A. Holman, T. Voepel-Lewis   +4 more
semanticscholar   +1 more source