Results 301 to 310 of about 158,913 (343)

Gene Therapy for Fragile X Syndrome, Challenges, and Promises

The Journal of Gene Medicine, Volume 27, Issue 11, November 2025.
Supplying the functional protein product of the FMR1 gene to the brain is an attractive concept for curative treatment of Fragile X syndrome. Despite existing challenges, recent developments establish the basis for developing efficient gene therapy protocols for this condition.
Milen Velinov
wiley   +1 more source

Intrathecal Therapies for Neurodegenerative Diseases: A Review of Current Approaches and the Urgent Need for Advanced Delivery Systems. [PDF]

Biomedicines
Schreiner TG, Menéndez-González M, Schreiner OD, Ciobanu RC.   +3 more
europepmc   +1 more source

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, Volume 62, Issue 5, Page 1280-1295, November 2025.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Management of High Spinal Anesthesia for Cesarean Section in the Semi-Fowler's Position. [PDF]

Cureus
Martin-Orr N, Villaluz JE, So B, Dhoon TQ, Holland M.   +4 more
europepmc   +1 more source

Exertion-Induced Intrathecal Haematoma in Undiagnosed Von Willebrand Disease: A Case of Acute Spinal Cord Compression. [PDF]

Cureus
Habib Z, Rasool MU, Ahmed A, Mohan R.
europepmc   +1 more source

Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI‐ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease

Movement Disorders, Volume 40, Issue 11, Page 2367-2380, November 2025.
Abstract Background Impaired glymphatic clearance may contribute to pathological accumulations in Parkinson's (PD), but how it interacts with other processes causing dementia remains unclear. Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) has been proposed as an indirect proxy for glymphatic clearance. Objectives To clarify DTI‐
Angeliki Zarkali, George Thomas, Ross Paterson, Naomi Hannaway, Ivelina Dobreva, Amanda J. Heslegrave, Elena Veleva, Henrik Zetterberg, Rimona S. Weil   +8 more
wiley   +1 more source

Elevating Labor Analgesia: The Impact of Low-Dose Intrathecal Ropivacaine-Sufentanil in Combined Spinal-Epidural Analgesia: A Prospective Double-Blinded Randomized Trial. [PDF]

Drug Des Devel Ther
Ji T, Xie L, Zhao T, Chen Z, Sun X, Zhang Y, Xu C.   +6 more
europepmc   +1 more source

Alcohol consumption and stroke: difficulties in assessing the relationships.

, 2002
Annie Britton, Criqui, Daniel Altmann, Giampiero Mazzaglia, Grønbaek, Hillbom, Imperiale, Klatsky, Mazzaglia   +8 more
core   +1 more source

T2 Hyperintensities in Gracile Tracts of Cervical Spinal Cord in Giant Axonal Neuropathy (GAN)

Muscle &Nerve, Volume 72, Issue 5, Page 1152-1155, November 2025.
ABSTRACT Introduction/Aims Giant axonal neuropathy (GAN) is a hereditary neurodegenerative disease due to the absence or loss of function of the gigaxonin gene. Pathologic findings in GAN are those of “dying‐back” axonal degeneration, in which the distal axon degenerates but the more proximal axon and neuronal cell body remain intact.
Diane Armao, Thomas W. Bouldin, Diana X. Bharucha‐Goebel, Terry S. Hartman, Steven J. Gray, Rachel M. Bailey, Dimah Saade, Joshua J. Todd, Minal Jain, Melissa Waite, Carsten G. Bönnemann, J. Keith Smith   +11 more
wiley   +1 more source

Optimized Kappa-Index Test Protocol to Detect Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis. [PDF]

Eur J Neurol
Björklund J, Itkonen O, Nokelainen P, Siuko M, Österlund-Tauriala E, Tienari PJ, Anttonen M.   +6 more
europepmc   +1 more source