Results 11 to 20 of about 17,145 (193)

Optimizing Contraceptive Counselling for Women with Migraine in a Primary Care Unit: A Quality Improvement Project

Gazeta Médica
INTRODUCTION: Contraceptive counselling plays a crucial role in Family Planning within Primary Healthcare. While combined hormonal contraceptives (CHC) are widely used, it is essential to consider alternatives for women diagnosed with migraine.
Rita Vasconcelos, Joana Sousa, Joana Ribeiro, Pedro Pereira, Bárbara Alvarenga, Mário Gomes, Maria Sá   +6 more
doaj   +1 more source

The association between levonorgestrel intrauterine devices and female fertility compared to other contraceptive methods: A historical cohort study. [PDF]

Int J Gynaecol Obstet
Abstract Objective This study aimed to investigate whether the use of levonorgestrel intrauterine devices (LNG‐IUD) is associated with an increased need for medically assisted reproductive (MAR) treatment compared to other contraceptive methods. Methods This register‐based historical cohort study included 733 875 Danish women aged 18–42 years between ...
Michaelsen MP, Nielsen LC, Poulsen M, Skals RG, Lundbye-Christensen S, Kesmodel US.   +5 more
europepmc   +2 more sources

Placement of an intrauterine device within 48 hours after early medical abortion—a randomized controlled trial

American Journal of Obstetrics and Gynecology, 2023
Intrauterine devices are safe, well-tolerated, and known to reduce the risk of unwanted pregnancies. At medical abortion, intrauterine devices are placed at a follow-up visit. Patients who miss this visit risk being left without contraception.This study aimed to investigate if placement of an intrauterine device within 48 hours of completed medical ...
Sara Hogmark, Karin Lichtenstein Liljeblad, Niklas Envall, Kristina Gemzell-Danielsson, Helena Kopp Kallner   +4 more
openaire   +4 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Knowledge and Training of Intrauterine Devices Among Primary Care Residents: Implications for Graduate Medical Education [PDF]

Journal of Graduate Medical Education, 2015
Nearly half of pregnancies in the United States are unintended, a rate that has increased recently, contrasted with a worldwide decline.1,2 This lack of progress may be due to low adoption of long-acting reversible contraceptives (LARCs). The United States has the lowest rate of intrauterine device (IUD) use of any industrialized country.3,4 Because ...
Aparna, Sridhar, Elizabeth Ruppel, Forbes, Kelly, Mooney, Radhika, Rible   +3 more
openaire   +2 more sources

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source