Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco +2 more
wiley +1 more source
Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]
, 2011 Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Börzsönyi, Balázs +7 more
core +2 more sources
BMEMat, EarlyView.MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen +10 more
wiley +1 more source
Association of Maternal Hypertension with Intrauterine Growth Retardation
Journal of Rawalpindi Medical College, 2017 To find out the association of intrauterine growth retardation (IUGR) with maternal hypertension. Methods: In this case control study 124 cases and 249 controls (thus giving the case to control ratio of 1:2.) were enrolled.
Isfandyar Khan
doaj +2 more sources
TO DETERMINE THE ASSOCIATION OF MATERNAL ANEMIA WITH PERINATAL OUTCOME IN TERTIARY CARE HOSPITAL
Pakistan Armed Forces Medical Journal, 2020 Objective: Determine the association of maternal anemia with perinatal outcome in tertiary care hospital. Study Design: Prospective study. Place and Duration of Study: Department of Gynecology and Obstetrics, Combined Military Hospital, Sialkot ...
Jehan Ara Rafiq Baig +3 more
doaj
Cases of intrauterine growth restriction identified in Las Tunas province, 2020
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2023 Background: intrauterine growth retardation has significant implications for neonatal morbidity and mortality. Objective: characterize the cases of intrauterine growth restriction identified in the Las Tunas province, in the period from January to ...
Onelis Núñez-López +1 more
doaj
, 2019 We develop an approach to risk classification based on quantile contours and allometric modelling of multivariate anthropometric measurements. We propose the definition of allometric direction tangent to the directional quantile envelope, which divides ...
Boghossian, Nansi S. +3 more
core +1 more source
Management of the child born small for gestational age through to adulthood: A consensus statement of the international societies of pediatric endocrinology and the Growth Hormone Research Society [PDF]
, 2007 Objective: Low birth weight remains a major cause of morbidity and mortality in early infancy and childhood. It is associated with an increased risk of health problems later in life, particularly coronary heart disease and stroke.
Cianfarani, S +5 more
core +1 more source
Structural and Functional Imaging of Motor Outcomes in Twins With Perinatal Stroke: A Case Report
Annals of the Child Neurology Society, EarlyView.ABSTRACT Background Perinatal arterial ischemic stroke (AIS) affects 1 in 4000 live births. Dystonia, affecting ~20% of children following AIS, is characterized by involuntary muscle contractions and abnormal movements. Why some develop dystonia post AIS, while others do not, remains unclear.
Prisca Hsu +8 more
wiley +1 more source
Role of venous Doppler evaluation of intrauterine growth retardation
The Egyptian Journal of Radiology and Nuclear Medicine, 2015 Aim of the work: The aim of this work is to determine the role of venous Doppler Ultrasonography for the prediction of adverse perinatal outcome in “intrauterine growth restricted fetus”, providing the obstetrician with additional information about the ...
Noha Mohamed AbdelMaboud +1 more
doaj +1 more source