Results 61 to 70 of about 69,059 (253)

Intravascular imaging in cardiovascular ageing

Experimental Gerontology, 2018
Ageing is related to complex molecular, inflammatory and biochemical changes that affect coronary pathology and often lead to coronary artery disease and cardiovascular events. Intravascular imaging is considered as the ideal technique to study coronary plaque morphology and assess its burden.
Bourantas CV, Crake T, Zhang Y-J, Ozkor M, Ahmed J, Garcia-Garcia HM, Serruys PW   +6 more
openaire   +4 more sources

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Despite the initial evidence supporting the utility of intravascular imaging to guide percutaneous coronary intervention (PCI), adoption remains low. Recent new trial data have become available.
Jayakumar Sreenivasan, Rohin K. Reddy, Yasser Jamil, Aaqib Malik, Daniel Chamie, James P. Howard, Michael G. Nanna, Gary S. Mintz, Akiko Maehara, Ziad A. Ali, Jeffrey W. Moses, Shao‐Liang Chen, Alaide Chieffo, Antonio Colombo, Martin B. Leon, Alexandra J. Lansky, Yousif Ahmad   +16 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Intravascular Imaging-Guided Versus Coronary Angiography-Guided Complex PCI: A Meta-analysis of Randomized Controlled Trials

Cardiology and Therapy
Introduction Trials evaluating the role of intravascular imaging in percutaneous coronary intervention (PCI) for complex coronary artery disease have yielded mixed results.
Mohamed Hamed, Sheref Mohamed, Mohamed Mahmoud, Jonathan Kahan, Amr Mohsen, Faisal Rahman, Waleed Kayani, Fernando Alfonso, Emmanuel S. Brilakis, Islam Y. Elgendy, Mamas A. Mamas, Ayman Elbadawi   +11 more
doaj   +1 more source

Debate: Intravascular ultrasound and optical coherence tomography in percutaneous revascularization. The OCT expert perspective

REC: Interventional Cardiology (English Ed.), 2020
QUESTION: Do you think there is enough evidence to indicate the use of intravascular imaging during percutaneous coronary interventions? ANSWER: Currently, there is enough evidence on the benefits provided by intracoronary imaging modalities during ...
Nieves Gonzalo
doaj   +1 more source

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source

Intravascular ultrasound imaging as a novel tool for the diagnosis of endofibrosis

Journal of Vascular Surgery Cases and Innovative Techniques, 2016
Given the rise of high-intensity sport athletes and the paucity of literature on endofibrosis, we describe a novel adjunctive imaging technique to aid in diagnosis. A 41-year-old female triathlete presented with exercise-limiting claudication. Results of
Danielle Campbell, MD, Elizabeth Andraska, BS, John Rectenwald, MD, Katherine Gallagher, MD   +3 more
doaj   +1 more source

Clinical Indications for Intravascular Ultrasound Imaging

Echocardiography, 2010
Intravascular ultrasound (IVUS) is a catheter‐based imaging modality, which provides high resolution cross‐sectional images of the coronary arteries. Unlike angiography, which displays only the opacified luminal silhouette, IVUS permits imaging of both the lumen and vessel wall and allows characterization of the type of the plaque.
Hoye, Angela, Bourantas, Christos V., Naka, Katerina K., Garg, Scot, Thackray, Simon, Papadopoulos, Dimitris, Alamgir, Farqad M., Michalis, Lampros K.   +7 more
openaire   +4 more sources