Results 191 to 200 of about 751,049 (345)

Strategic Timing of Gene Silencing: Cellular Kinetics‐Based Administration of siRNA for Optimized Photothermal Cancer Treatment

open access: yesAdvanced Science, EarlyView.
Coordinating therapy with gene expression kinetics emerges as a key strategy for maximizing nanomedicine efficacy in aggressive cancers. A hybrid nanocarrier delivering HSP70‐targeting siRNA demonstrates this chronotherapeutic principle through systematic cellular profiling.
Tianliang Fang   +6 more
wiley   +1 more source

Effects of anesthesia on tumor perfusion and infiltration during brain tumor neurosurgery. [PDF]

open access: yesAnn Med Surg (Lond)
Dhingra A   +6 more
europepmc   +1 more source

Targeting of the CD161 Inhibitory Receptor Enhances Bone‐Marrow‐Resident Memory CD8+ T‐Cell‐Mediated Immunity against Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
CD161 is identified as a novel inhibitory receptor on bone marrow (BM)‐resident CD8⁺ T cells in multiple myeloma (MM). Through interaction with its ligand CLEC2D, CD161 impairs T‐cell function and promotes immune suppression. Blockade of CD161 restores tissue residency and cytotoxicity of CD8⁺ T cells and enhances chimeric antigen receptor T‐cell (CAR ...
Liwen Wang   +16 more
wiley   +1 more source

Assessment of Anesthetic Modalities in Otologic Surgery. [PDF]

open access: yesOtol Neurotol Open
Bao PH   +5 more
europepmc   +1 more source

New Intravenous Anesthetics

open access: yesJournal of the Korean Medical Association, 2001
openaire   +2 more sources

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

open access: yesAdvanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong   +9 more
wiley   +1 more source

Effect of Intravenous Anesthetics on Spontaneous and Endotoxin‐stimulated Cytokine Response in Cultured Human Whole Blood

open access: yesAnesthesiology, 1998
B. Larsen   +5 more
semanticscholar   +1 more source

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

open access: yesAdvanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao   +6 more
wiley   +1 more source

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