Results 231 to 240 of about 751,049 (345)

Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

open access: yesAdvanced Intelligent Systems, EarlyView.
Intravascular electroencephalography (ivEEG) using micro‐intravascular electrodes was developed. Cortical‐vein ivEEG showed a higher signal‐to‐noise ratio and finer spatial resolution of somatosensory evoked potentials (SEPs) than superior sagittal sinus ivEEG, and deep‐vein ivEEG captured clear visual evoked potentials.
Takamitsu Iwata   +15 more
wiley   +1 more source

Intratympanic dexamethasone microcrystals/lidocaine‐loaded PLGA non‐spherical microparticles for local drug delivery to the inner ear

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Optimized lidocaine‐loaded PLGA non‐spherical particles (LPNMs) and dexamethasone microcrystals (DEX MCs) were prepared. They were then mixed in sodium hyaluronate solution to obtain a co‐delivery system, administrated in guinea pigs to evaluate the pharmacokinetics and biocompatibility of the system.
Dongcheng Wang   +7 more
wiley   +1 more source

Development of an efficient mice model of cancer‐associated cardiac cachexia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong   +9 more
wiley   +1 more source

Changes in hemodynamics of pulmonary artery using Flowire in a canine model of acute pulmonary thromboembolism

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study investigated changes in pulmonary artery hemodynamics using a Flowire catheter and evaluated the accuracy of Doppler echocardiography in dogs with acute pulmonary thromboembolism (PTE). Ten healthy beagles were anesthetized, and acute pulmonary hypertension (PH) was induced by injecting 300‐μm dextran microspheres.
Tomohiko Yoshida   +3 more
wiley   +1 more source

Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice

open access: yesAnnals of Neurology, EarlyView.
This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije   +9 more
wiley   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

open access: yesAnnals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff   +7 more
wiley   +1 more source

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