High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
core +1 more source
Maternal analgosedation and breastfeeding: guidance for the pediatrician
Journal of Pediatric and Neonatal Individualized Medicine, 2015 As part of analgosedative treatment modalities after delivery (e.g. caesarean related pain, birth related trauma, pre-existing pain syndromes), mothers are treated with different analgosedatives that may also affect the nursing infant.
Karel Allegaert +1 more
doaj +1 more source
NF‐kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol
FEBS Open Bio, 2020 Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown.
Keiko Oda‐Kawashima +13 more
doaj +1 more source
Cardiac output and the pharmacology of general anesthetics: a narrative review
Colombian Journal of Anesthesiology, 2023 The relationship between cardiac output and anesthetic drugs is important to anesthesiologists, since cardiac output determines the speed with which a drug infused into the bloodstream reaches its target and the intensity of the drug’s effect.
Elena Simón-Polo +3 more
doaj +1 more source
The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]
, 2012 This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L +5 more
core +1 more source
INHALATION SEDATION IN THE PATIENTS AFTER CARDIAC SURGERY IN INTENSIVE CARE UNITS
Вестник анестезиологии и реаниматологии, 2018 From the time when special tools for delivery of volatile anesthetics in the intensive care units (ICU) became available, inhalation sedation is getting more and more popular among emergency physicians.
V. V. Likhvantsev +5 more
doaj +1 more source
Structural interplay of anesthetics and paralytics on muscle nicotinic receptors
Nature Communications, 2023 General anesthetics and neuromuscular blockers are used together during surgery to stabilize patients in an unconscious state. Anesthetics act mainly by potentiating inhibitory ion channels and inhibiting excitatory ion channels, with the net effect of ...
Umang Goswami +3 more
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Comparing Intravenous And Inhalation Anesthetics For Intraoperative Anesthesia In Adult Patients With An Acute Traumatic Brain Injury [PDF]
, 2022 As research and science has progressed to further analyze the effects of anesthetics on cerebral physiology, the margin of safety for each anesthetic is reassessed to enhance patient outcomes and recovery.
Moody, Natasha K.
core +1 more source
anesthetic: nested sampling visualisation [PDF]
Journal of Open Source Software, 2019, 4(37), 1414, 2019 anesthetic is a Python package for processing nested sampling runs, and will be useful for any scientist or statistician who uses nested sampling software. anesthetic unifies many existing tools and techniques in an extensible framework that is intuitive for users familiar with the standard Python packages, namely NumPy, SciPy, Matplotlib and pandas.
arxiv +1 more source
Effects of Anesthetics on Barrier Tissue Function
Journal of Immunology Research, 2019 Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. Barrier tissues play critical roles in human health and diseases, yet the impacts of anesthetics on barrier tissues are ...
Fujing Wang +4 more
doaj +1 more source