Results 41 to 50 of about 4,963,319 (355)

Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus

Nature Medicine, 2019
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation.
R. Dedrick, Carlos A. Guerrero-Bustamante, R. Garlena, D. Russell, K. Ford, K. Harris, K. Gilmour, J. Soothill, D. Jacobs-Sera, R. Schooley, G. Hatfull, H. Spencer   +11 more
semanticscholar   +1 more source

Closed-Loop Intravenous Drug Administration Using Photoplethysmography

IEEE Journal of Translational Engineering in Health and Medicine, 2018
An optically-based injection control system has been developed for preclinical use for an intravenous drug delivery application. Current clinical drug delivery for oncology typically provides for intravenous administration without an awareness of ...
George W. Carpenter, Holly G. Myers, Eric A. Sherer, Katie A. Evans, D. Patrick O'Neal   +4 more
doaj   +1 more source

Acute infections in intravenous drug users.

Clinical medicine (London), 2013
#### Key points Intravenous drug users (IDUs) are vulnerable to a wide range of potentially life-threatening infections, including rare infections such as wound botulism and cutaneous anthrax All active and previous IDUs should be offered blood-borne ...
T. Lavender, B. Mccarron
semanticscholar   +1 more source

The clinical pharmacology of intranasal l-methamphetamine. [PDF]

, 2008
BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom, Foster, Elyse, Harris, Debra S, Jacob, Peyton, Jones, Reese T, McGlothlin, Dana, Mendelson, John E   +6 more
core   +2 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography

Pharmaceutics, 2022
Intravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operation ...
Yingying Zhou, Xiazi Huang, Jiyu Li, Ting Zhu, Weiran Pang, Larry Chow, Liming Nie, Lei Sun, Puxiang Lai   +8 more
doaj   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
AA Poltera, Amy Jones, B Evrard, B Raz, Barbara Bradley, BJ Berger, C Burri, C Burri, CA Hunter, Christopher McCabe, E Torreele, EW Hurst, FIC Apted, FW Jennings, George Gettinby, H Hirumi, J Opigo, J Pepin, J Pepin, J Rodgers, J Rodgers, Jayne Raper, Jean Rodgers, JH Zar, JLM Atouguia, JW Wong, Michael P. Barrett, MP Barrett, MP Barrett, NJ Abbott, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, RL Carrier, S Ben Zirar, S Gibaud, SL Soignet, Stéphane Gibaud, T Loftsson, T Loftsson, V Lejon, VJ Stella   +45 more
core   +7 more sources

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

Acute Hepatic Porphyrias: Review and Recent Progress. [PDF]

, 2019
The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.
Andant, Anderson, Andersson, Badawy, Balwani, Bissell, Bissell, Bloomer, Bonkovsky, Bonkovsky, Bonkovsky, Bonkovsky, Bonkowsky, Bonkowsky, Bonkowsky, Bylesjo, Chen, D’Avola, Ferrer, Glueck, Handschin, Jeans, Lambrecht, Lane, Marsden, McGuire, Pallet, Sardh, Sardh, Shen, Singal, Stein, Stewart, Tchernitchko, Wahlin, Watson, Watson, Willandt, Wu, Yarra, Yasuda   +40 more
core   +1 more source

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Nature Communications, 2019
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug ...
Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, A. Hakeem, Jun Hu, L. Gan, H. Santos, Xiangliang Yang   +10 more
semanticscholar   +1 more source