Results 201 to 210 of about 136,252 (258)

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Persistent (patent) foramen ovale assessment and closure for the general physician. [PDF]

Clin Med (Lond)
Wilmshurst P.
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

In vivo self-assembled SOD1-siRNAs mitigate muscle atrophy and denervation in amyotrophic lateral sclerosis. [PDF]

Brain
Guo J, Zou Q, Xu J, Lei J, Yin X, Li B, Fu J, Mi J, Wang Y, Huang H, Zhang CY, Chen X.   +11 more
europepmc   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

An observational study on the effects of as-needed use of various antipsychotic drugs for agitation due to psychotic disorders. [PDF]

Int Clin Psychopharmacol
Hatta K, Morikawa F, Yamasaki S, Ishizuka T, Nakamura M, Hino K, Katayama S, Imai A, Fujita K, Sugiyama N, JAST study group.   +10 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Subcutaneously Administered Tislelizumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer: Pharmacokinetics and Safety Results from the BGB-A317-103 Phase I Study. [PDF]

Clin Cancer Res
Chen M, Bulat I, Maglakelidze M, Li N, Chen Z, Kong W, Li Y, Fang J, Zhang J, Zhang J, Wang B, Ma J, Sun Y, Wang Q, Chen X, Liu X, Yu T, Hanley WD, Budha N, Li H, Lin X, Niu Z, Jamal L, Abdrashitov R, Wang M.   +24 more
europepmc   +1 more source

Stem Cells and Their Derivatives in Cardiac Fibrosis Therapy: Challenges and Perspectives. [PDF]

Cells
Piwowar A, Zolbach Z, Rydzek J, Skonieczna N, Rojek K, Żołyniak M, Soczyńska J, Woźniak S.   +7 more
europepmc   +1 more source

MSC-EVs Prevent Abdominal Aortic Aneurysm Formation by Inhibiting Perivascular Adipose Tissue-Induced NET Release. [PDF]

Stem Cells Int
Sun X, Zhao C, Tu K, Guan X, Lv L, Xue G, Yang S.   +6 more
europepmc   +1 more source