Results 291 to 300 of about 2,150,754 (399)

A Hypoxia‐Responsive Single‐Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque

open access: yesAdvanced Science, EarlyView.
A tetranitrogen‐coordinated single‐atom manganese catalyst (SMC) is fabricated with outstanding sonosensitization efficiency and multi‐enzyme‐like catalytic properties. To enable better targeting of M1 macrophages, hyaluronic acid (HA) is applied to modify the surface of SMC, yielding SMC‐HA nanozymes.
Qiaofei Chen   +14 more
wiley   +1 more source

Plain language summary on subcutaneous administration of isatuximab in people with relapsed and/or refractory multiple myeloma. [PDF]

open access: yesFuture Oncol
Quach H   +9 more
europepmc   +1 more source

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

open access: yesAdvanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao   +20 more
wiley   +1 more source

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam [PDF]

open access: yes, 2018
Akk, Gustav   +9 more
core   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

open access: yesAdvanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang   +9 more
wiley   +1 more source

Engineered Substrate‐Free Small Molecules for Enhanced Raman Scattering and Photothermal Conversion Efficiency

open access: yesAdvanced Science, EarlyView.
A molecular engineering strategy is developed to increase the stacking‐induced intermolecular charge transfer‐enhanced Raman scattering (SICTERS) intensity and photothermal conversion efficiency of electron donor‐acceptor‐donor (D–A–D) molecules. This approach enables to design SICTERS‐mediated photo‐theranostic agents for substrate‐free Raman image ...
Sheng Yu   +9 more
wiley   +1 more source

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