Results 131 to 140 of about 120,760 (361)

Evaluation of HER2 Targeted Poly(Ethylene Glycol)‐Poly(L‐histidine) Copolymer Micelles in Breast Cancer Models

Macromolecular Bioscience, EarlyView.
This study reports on the in vitro, ex vivo, and in vivo evaluation of HER2 targeted biodegradable micelle variants, conjugated with trastuzumab, with or without the drug doxorubicin or the dye rhodamine B. Findings indicate enhanced cellular association and efficacy of trastuzumab‐conjugated micelles in HER2 positive breast cancer models, showing ...
Remya Valsala Kumari, Abhilash D. Pandya, Solveig J. Pettersen, Audun Kvalvaag, Anne Grethe Myrann, Razvan Ghiarasim, Alexandru Rotaru, Mihail‐Gabriel Dimofte, Tore Skotland, Kirsten Sandvig, Gunhild Mari Mælandsmo, Tore‐Geir Iversen   +11 more
wiley   +1 more source

Review of hypoxaemia in the anaesthetized horse: predisposing factors, consequences and management [PDF]

, 2017
Objectives: To discuss how hypoxaemia might be harmful and why the horse is particularly predisposed to developing it. To review the strategies that are used to manage hypoxaemia in anaesthetised horses, to describe how successful these strategies are
Auckburally, Adam, Nyman, Görel
core   +1 more source

Dynamic contrast enhanced‐magnetic resonance fingerprinting (DCE‐MRF): A new quantitative MRI method to reliably assess tumor vascular perfusion

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose The clinical utility of conventional DCE‐MRI methods is limited by the use of conventional qualitative dynamic T1‐weighted images, resulting in poor reproducibility. This study presents the initial implementation of a new DCE‐magnetic resonance fingerprinting (DCE‐MRF) methodology to provide reproducible, quantitative assessments of ...
Christina J. MacAskill, Yuran Zhu, Guanhua Wang, Bernadette O. Erokwu, Chetan B. Dhakan, Andrew Dupuis, Barbara J. Schiemann, Michael Kavran, Chunying Wu, William P. Schiemann, Mark A. Griswold, Xin Yu, Mark D. Pagel, Chris A. Flask   +13 more
wiley   +1 more source

Adding magnesium to lidocaine for intravenous regional anesthesia

Journal of Research in Medical Sciences, 2008
<ul> <li><strong>BACKGROUND</strong>: Magnesium (Mg) has been used as an adjuvant medication in postoperative analgesia. We planed this study to assess the effects of Mg, when added to lidocaine in intravenous regional anesthesia (
Parviz Kashefi, Kamran Montazeri, Azim Honarmand, Abdolah Moradi, Seyed Gholamreza Masoomi   +4 more
doaj  

Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]

, 2017
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco, Carron, Michele, Ieppariello, Giovanna   +2 more
core   +1 more source

Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma

Small Science, EarlyView.
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim, Han Sol Lee, June Hong Ahn, Tae‐Wan Kwon, So‐Yeol Yoo, Donghyuk Seo, Sang Kyum Kim, Hee Ho Park, Seung‐Woo Cho, Wonhwa Lee, Jae‐Young Lee, Hong Nam Kim   +11 more
wiley   +1 more source

HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. [PDF]

, 2019
BACKGROUND AND OBJECTIVES: There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release,
Gimbel, Joseph S., Hu, Jia, Lee, Gwo-Chin, Pollack, Richard A., Viscusi, Eugene R.   +4 more
core   +1 more source

Preliminary non‐comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate

Veterinary Record, EarlyView.
Abstract Background Challenges associated with bowel cleansing protocols for canine colonoscopy include practical applicability and inadequate preparations. This study aimed to describe and evaluate an adapted protocol to simplify colonoscopy preparation in dogs.
Julia Elia da Silva Paranhos, Melissa Guillen Gonçalves de Souza, Daniela Araujo de Sousa, Debora Costabile Soibelman, Sabrina Martins da Costa Ferreira, Juliana da Silva Leite, Bruno Penna, Ana Maria Reis Ferreira   +7 more
wiley   +1 more source

Neuroprotective effects of remote limb ischemic preconditioning through enhanced cerebral blood flow via activation of the PI3K/AKT pathway in ischemic stroke

VIEW, EarlyView.
Stroke is a leading cause of death and disability worldwide, often due the inadequate restoration of cerebral blood flow following vascular recanalization. Our study demonstrates that a simple technique called RLIPC (remote limb ischemic preconditioning), which involves briefly restricting blood flow in a limb, protects the brain during a stroke by ...
Chaoran Dou, Diwen Tang, Yulin Yan, Wen Shui, Minzhi Zhou, Bin Chen, Lishuai Feng, Benhao Li, Tao Ying   +8 more
wiley   +1 more source

Patient anxiety and modern elective surgery: a literature review [PDF]

, 2003
Medical advances have led to a considerable rise in the level of elective surgery undertaken as day-case surgery and with minimal hospital stay. However, amid such advances, preoperative psychological care has remained relatively static.
Mitchell, MJ
core   +1 more source