Results 271 to 280 of about 120,760 (361)

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

open access: yesMedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li   +8 more
wiley   +1 more source

Tracking Hyperpolarized [1‐13C] Pyruvate and [1‐13C] L‐Lactate Metabolism in the Healthy and Post‐Stroke Mouse Brain

open access: yesNMR in Biomedicine, Volume 38, Issue 8, August 2025.
Hyperpolarized [1‐13C] pyruvate and [1‐13C] lactate provide complementary views on the same metabolic pathways. We investigated their performance as cerebral metabolic contrast agents in healthy mice and mice subjected to transient ischemia. We found that the cerebral metabolism of both substrates was significantly altered after ischemia and discuss ...
Thanh Phong Lê   +8 more
wiley   +1 more source

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations

open access: yesWorld Journal of Surgery, Volume 49, Issue 8, Page 2029-2054, August 2025.
ABSTRACT Background Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology.
Timothy C. Hardcastle   +14 more
wiley   +1 more source

Toward Identifying a Multivariate Correlation of Septic Arthritis With a Machine Learning Approach: Time to Reset the Current Australasian Guidelines?

open access: yesInternational Journal of Rheumatic Diseases, Volume 28, Issue 8, August 2025.
ABSTRACT Objectives To understand the complexity of disease pathology through the prism of septic arthritis, especially the reliability of popular and, yet, arbitrary thresholds like synovial leucocyte counts of ≥ 100,000/μL suggestive of it, with the help of statistical analysis and logistic regression. Methods An anonymized patient dataset comprising
Sourav Bhattacharjee   +4 more
wiley   +1 more source

Anesthetic Management in Combined Off-Pump CABG and EC-IC Bypass for CAD and Moyamoya Disease. [PDF]

open access: yesJACC Case Rep
Zhang J   +9 more
europepmc   +1 more source

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