Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
The intrinsic bayes factor described by an example [PDF]
The Intrinsic Bayes Factor (IBF) has been recently introduced by Berger and Pericchi (1996) for automatic model selection and hypothesis testing in a Bayesian framework.
Pericchi, L. R., Presa, E., Fiteni, I.
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Role of calcium and phosphorous concentration as an intrinsic factor in the development of skull fracture following road traffic accidents. [PDF]
Tamuli RP +3 more
europepmc +1 more source
Some experiments on intrinsic factor [PDF]
N G, HEATLEY, M A, SHEIKH, K B, TAYLOR
openaire +2 more sources
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
DIVALENT CATION AND PH DEPENDENCE OF RAT INTRINSIC FACTOR ACTION IN EVERTED SACS AND MUCOSAL HOMOGENATES OF RAT SMALL INTESTINE * [PDF]
In 1959 it was reported in these pages (1) that hog intrinsic factor concentrate enhanced the uptake of radioactive vitamin B12 (Co60-B12) by everted sacs of rat small intestine in the cold.
Victor Herbert, William B
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Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia. [PDF]
Cittolin-Santos GF +3 more
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Satisfaction with creativity: a study of organisational characteristics and individual motivations [PDF]
In answering the question of what influences satisfaction for creativity in the workplace, this work takes into account the extent to which the organization supports human aspiration to creativity. The empirical model uses survey data encompassing over 4,
Silvia Sacchetti, Ermanno C. Tortia
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