Results 101 to 110 of about 361,243 (290)
Electronic Journal of Differential Equations, 2007 The paper studies energy functionals on quasimetric spaces, defined by quadratic measure-valued Lagrangeans. This general model of medium, known as metric fractals, includes nested fractals and sub-Riemannian manifolds.
Kyril Tintarev
doaj
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Whitney's Problem on Extendability of Functions and an Intrinsic Metric
Advances in Mathematics, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +4 more sources
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
International Journal of Applied Mathematics and Computer Science, 2015 One of the problems in the analysis of the set of images of a moving object is to evaluate the degree of freedom of motion and the angle of rotation. Here the intrinsic dimensionality of multidimensional data, characterizing the set of images, can be ...
Karbauskaitė Rasa, Dzemyda Gintautas
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Intrinsic metrics in complete circular domains
Mathematische Annalen, 1990 The purpose of this paper is to study the behavior of the Kobayashi and Carath6odory pseudodistances and (infinitesimal) pseudometrics near the origin of complete circular domain in a complex locally convex separate topological vector space. Let V be a locally convex separate topological vector space over the field C of the complex numbers.
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Intrinsic Dimensionality as a Metric for the Impact of Mission Design Parameters [PDF]
, 2022 Kerry Cawse‐Nicholson +10 more
openalex +1 more source