Results 81 to 90 of about 361,243 (290)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Cumulative Dragging - An Intrinsic Characteristic of Stationary Axisymmetric Spacetime
, 1997 The Cumulative Drag Index defined recently by Prasanna has been generalised to include the centrifugal acceleration. We have studied the behaviour of the drag index for the Kerr metric and the Neugebauer-Meinel metric representing a self-gravitating ...
A.R. Prasanna +9 more
core +1 more source
Surface Simplification using Intrinsic Error Metrics
ACM Transactions on Graphics, 2023 This paper describes a method for fast simplification of surface meshes. Whereas past methods focus on visual appearance, our goal is to solve equations on the surface. Hence, rather than approximate the extrinsic geometry, we construct a coarse intrinsic triangulation of the input domain. In the spirit of the
Hsueh-Ti Derek Liu +5 more
openaire +2 more sources
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Measurement of job motivation in TEDS-M: testing for invariance across countries and cultures
Large-scale Assessments in Education, 2016 The paper presents the challenges of cross-country and cross-cultural research on the motivation to become a mathematics teacher based on data from the “Teacher Education and Development Study in Mathematics (TEDS-M)”.
Christin Laschke, Sigrid Blömeke
doaj +1 more source
Intrinsic connections for Levi metrics
Manuscripta Mathematica, 1992 It is supposed that a CR manifold carries a metric which, on the maximal complex subspace of the tangent space, agrees with a choice of a Levi form. By using Cartan's moving frame method the local equivalence problem is solved. Then this solution is interpreted as a connection in a principal bundle. Finally, there are obtained the curvature and torsion
openaire +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Isometries of intrinsic metrics on strictly convex domains
Mathematische Zeitschrift, 1987 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
PATRIZIO, GIORGIO +2 more
openaire +3 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source