Results 101 to 110 of about 300,548 (279)
Intrinsic Metric on Graded Graphs, Standardness, and Invariant Measures [PDF]
Journal of Mathematical Sciences, 2014 We define a general notion of a smooth invariant (central) ergodic measure on the space of paths of an $N$-graded graph (Bratteli diagram). It is based on the notion of standardness of the tail filtration in the space of paths, and the smoothness criterion uses the so-called intrinsic metric which can be canonically defined on the set of vertices of ...
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
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Scientific ReportsThe hippocampal CA2 region has recently been linked to oscillatory activity, spatial navigation, and social behavior. Its predominant neuronal population, CA2 pyramidal neurons (CA2-PNs), critically contributes to hippocampal computations, yet the ...
Pia Kruse +3 more
doaj +1 more source
Note on intrinsic metrics on graphs
Mathematische NachrichtenAbstractWe study the set of intrinsic metrics on a given graph. This is a convex compact set and it carries a natural order. We investigate existence of largest elements with respect to this order. We show that the only locally finite graphs which admit a largest intrinsic metric are certain finite star graphs.
Lenz, Daniel +2 more
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Geometric flows and (some of) their physical applications
, 2005 The geometric evolution equations provide new ways to address a variety of non-linear problems in Riemannian geometry, and, at the same time, they enjoy numerous physical applications, most notably within the renormalization group analysis of non-linear ...
Bakas, I.
core
Intrinsic metrics in complete circular domains
Mathematische Annalen, 1990 Let \(D\) be a complete circular domain in a locally convex separate topological vector space. Let \(k_ D\) and \(c_ D\) be respectively the Kobayashi and Carathéodory pseudodistance and let \(\kappa_ D\) and \(\gamma_ D\) be the corresponding infinitesimal pseudometrics; denote also by \(k^ 1_ D\) the ``one-disc'' Kobayashi pseudodistance, that is ...
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
An intrinsic metric for parts [PDF]
Proceedings of the American Mathematical Society, 1967 Bear, H. S., Weiss, M. L.
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