Results 71 to 80 of about 300,548 (279)
Frontiers in Neuroscience, 2018 The resting activity of the brain can be described by so-called intrinsic connectivity networks (ICNs), which consist of spatially and temporally distributed, but functionally connected, nodes.
Stavros I. Dimitriadis +14 more
doaj +1 more source
Geometric Time and Causal Time in Relativistic Lagrangian Mechanics [PDF]
, 2016 In this article, we argue that two distinct types of time should be taken into account in relativistic physics: a geometric time, which emanates from the structure of spacetime and its metrics, and a causal time, indicating the flow from the past to the ...
Brunet, Olivier
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
NeuroImageResting-state functional magnetic resonance imaging (rs-fMRI) is a prominent tool for investigating functional deficits in stroke patients. However, the extent to which the hemodynamic lags (LAG) and the intrinsic cerebrovascular reactivity (iCVR) may ...
Luoyu Wang +10 more
doaj +1 more source
Characterizing donation behavior from psychophysiological indices of narrative experience
Frontiers in Neuroscience, 2015 Research on narrative persuasion has yet to investigate whether this process influences behavior. The current study explored whether: 1) a narrative could persuade participants to donate to a charity, a prosocial, behavioral decision; 2 ...
Kelly Anne Correa +4 more
doaj +1 more source
Export of miRNAs from activated macrophages is cooperative and HuR‐dependent
FEBS Letters, EarlyView.This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intrinsic connections for Levi metrics
Manuscripta Mathematica, 1992 It is supposed that a CR manifold carries a metric which, on the maximal complex subspace of the tangent space, agrees with a choice of a Levi form. By using Cartan's moving frame method the local equivalence problem is solved. Then this solution is interpreted as a connection in a principal bundle. Finally, there are obtained the curvature and torsion
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source