Results 81 to 90 of about 300,548 (279)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Environmental Research Letters, 2016 To assess the biogeophysical impacts of land cover/land use change (LCLUC) on surface temperature, two observation-based metrics and their applicability in climate modeling were explored in this study.
Liang Chen, Paul A Dirmeyer
doaj +1 more source
Intrinsically Hölder Sections in Metric Spaces
WSEAS TRANSACTIONS ON MATHEMATICSWe introduce the notion of intrinsically Holder graphs in metric spaces that generalized the one of ¨ intrinsically Lipschitz sections. This concept is relevant because it has many properties similar to Holder maps but ¨ is profoundly different from them.
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
On the holomorphic curvature of some intrinsic metrics [PDF]
Proceedings of the American Mathematical Society, 1977 If G is a hyperbolic manifold in the sense of Kobayashi and the differential Kobayashi metric K G {K_G} is of class C 2 {C^2} , then the holomorphic curvature of K G {K_G} is greater than or ...
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
CrossDI: A comprehensive dataset crossing three databases for calculating disruption indexes
Scientific DataThe Disruption Index (DI) is a significant metric for identifying research that expands scientific frontiers and pioneers new fields. Unlike readily accessible metrics like citation counts, DI requires complex analysis of citation patterns, specifically,
Shuo Xu +3 more
doaj +1 more source
Error metrics determination in functionally approximated circuits using SAT solvers.
PLoS ONE, 2020 Approximate computing is an emerging design paradigm that offers trade-offs between output accuracy and computation efforts by exploiting some applications' intrinsic error resiliency.
Sa'ed Abed +2 more
doaj +1 more source