Results 41 to 50 of about 568,428 (265)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

An Eulerian Single-Phase Transport Model for Solid Fission Products in the Molten Salt Fast Reactor: Development of an Analytical Solution for Verification Purposes

Frontiers in Energy Research, 2021
Nuclear reactor modeling has been shifting, over the last decades, towards full-core multiphysics analysis due to the ever-increasing safety requirements and complexity of the designs of innovative systems.
Andrea Di Ronco, Andrea Di Ronco, Stefano Lorenzi, Francesca Giacobbo, Antonio Cammi, Antonio Cammi   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Linagliptin–-A Novel Dipeptidyl Peptidase Inhibitor for Type 2 Diabetes Therapy

Clinical Medicine Insights: Endocrinology and Diabetes, 2012
Incretin based therapies have been introduced into the treatment options of type 2 diabetes a few years ago. Among them, the orally active DPP-4 inhibitors have established themselves as insulinotropic agents.
Baptist Gallwitz
doaj   +1 more source

Testing of low-current equipment in explosive atmospheres [PDF]

MATEC Web of Conferences
All activities involving flammable substances capable of generating an atmosphere mixed with air, in the form of gases, vapors, flammable fog, or dust may involve a danger of explosion.
Beldiman Alexandru Marian, Pupăzan Gabriela   +1 more
doaj   +1 more source

Alcohol and other drugs in the Australian construction industry: a pathway for safety focused cultural change [PDF]

, 2013
Background: Anecdotal evidence from the infrastructure and building sectors highlights issues of alcohol and other drugs (AODs) and its association with safety risk on construction sites.
Biggs, Herbert, Williamson, Amy
core   +1 more source

Husserl on Hallucination: A Conjunctive Reading [PDF]

, 2020
Several commentators have recently attributed conflicting accounts of the relation between veridical perceptual experience and hallucination to Husserl.
Bower, Matt E.
core  

Consumer attitudes and preference exploration towards fresh-cut salads using best–worst scaling and latent class analysis [PDF]

, 2019
This research explored the preferences and buying habits of a sample of 620 consumers of fresh-cut, ready-to-eat salads. A best–worst scaling approach was used to measure the level of preference stated by individuals regarding 12 attributes for quality ...
Bargetto A., Borra D., Massaglia S., Merlino V. M., Peano C., Sottile F.   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source