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Recent advances in atomic molecular dynamics simulation of intrinsically disordered proteins.

Physical Chemistry, Chemical Physics - PCCP, 2020
Intrinsically disordered proteins (IDPs) play important roles in cellular functions. The inherent structural heterogeneity of IDPs makes the high-resolution experimental characterization of IDPs extremely difficult.
Wenning Wang
semanticscholar   +1 more source

Exploring Protein Intrinsic Disorder with MobiDB

2020
Nowadays, it is well established that many proteins or regions under physiological conditions lack a fixed three-dimensional structure and are intrinsically disordered. MobiDB is the main repository of protein disorder and mobility annotations, combining different data sources to provide an exhaustive overview of intrinsic disorder.
Monzon A. M.   +4 more
openaire   +3 more sources

General Purpose Water Model Can Improve Atomistic Simulations of Intrinsically Disordered Proteins.

Journal of Chemical Theory and Computation, 2019
Unconstrained atomistic simulations of intrinsically disordered proteins and peptides (IDP) remain a challenge: widely used, "general purpose" water models tend to favor overly compact structures relative to experiment.
P. Shabane, S. Izadi, A. Onufriev
semanticscholar   +1 more source

Functions of intrinsic disorder in transmembrane proteins

Cellular and Molecular Life Sciences, 2017
Intrinsic disorder is common in integral membrane proteins, particularly in the intracellular domains. Despite this observation, these domains are not always recognized as being disordered. In this review, we will discuss the biological functions of intrinsically disordered regions of membrane proteins, and address why the flexibility afforded by ...
Kjærgaard, Magnus   +1 more
openaire   +4 more sources

Conformational ensembles of the human intrinsically disordered proteome.

Nature
Giulio Tesei   +7 more
semanticscholar   +1 more source

Intrinsic Disorder and Protein Function

Biochemistry, 2002
Celeste J. Brown   +4 more
openaire   +2 more sources

Nanooncology: The future of cancer diagnosis and therapy

Ca-A Cancer Journal for Clinicians, 2013
Avnesh S Thakor
exaly  

MicroRNAome genome: A treasure for cancer diagnosis and therapy

Ca-A Cancer Journal for Clinicians, 2014
Ioana Berindan-neagoe   +2 more
exaly  

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