Results 141 to 150 of about 11,841,139 (263)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Evaluation of the fodder stocks for the Przewalski horse Equus ferus przewalskii on the «Pre-Ural steppe» plot of the Orenburg State Nature Reserve

Nature Conservation Research: Заповедная наука, 2016
In 2015 the Federal Government Funded Institution «Orenburg Reserves» started the Programme of Establishing of a Semi-Free Population of the Przewalski Horse at the Orenburg Reserve on the territory of the steppe area «Pre-Ural Steppe».
Tatjana L. Zharkikh, Lyubov G. Linerova
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Association between the timing of chewable complementary food introduction and functional speech disorders in children: a case-control study. [PDF]

Front Pediatr
Li H, Huang G, Qi Q.
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Serosurveillance and participatory disease surveillance of Peste des Petits Ruminants (PPR) in Georgia and Armenia in 2019-2020. [PDF]

BMC Vet Res
Baron JN, Vepkhvadze NG, Markosyan T, Gulbani A, Enukidze T, Basiladze V, Chaligava T, Khelaia D, Kartskhia N, Kurashvili T, Kharatyan S, Sargsyan K, Goginashvili K, Kokhreidze M, Tigilauri T, Toklikishvili N, Turmanidze M, Mamisashvili E, Ståhl K, Risatti G, Chenais E.   +20 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Qualitative risk assessment of Japanese encephalitis virus introduction and transmission in Pacific Island countries and territories. [PDF]

PLoS Negl Trop Dis
Skinner EB, Murphy AK, Yu F, Moore KT, Chen-Cao L, Williams DT, Karl S, Goi J, Lau CL, Sartorius B.   +9 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source