Results 211 to 220 of about 21,854,217 (256)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An Introduction to Competing Risks in Epidemiology [Letter]. [PDF]

Clin Epidemiol
Muñoz A, Ng DK.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A comparative study of the quality control efficacy of multiple error-introduction methods for patient-based real-time quality control. [PDF]

Pract Lab Med
Dong X, Liu J, Li B, Wen D, Han H.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Implementation of early peanut introduction among providers in a southern US state. [PDF]

J Allergy Clin Immunol Glob
Margiotta C, Seminara E, Pesek RD, Jefferson AA, Doan D, Price A, Kennedy JL, Hiegel A, Boone M, Brown AW, Scurlock AM, Perry TT, Jones SM.   +12 more
europepmc   +1 more source

Mucopolysaccharidosis IIID and Beta-Mannosidosis in Brazilian Anglo-Nubian Goats: Molecular and Genealogical Insights for the Development and Implementation of a Genetic Disease Eradication Program. [PDF]

Anim Genet
Bezerra FCM, Belli LSBP, Novais JMCB, Ibelli AMG, Santos CRO, Gouveia GV, Macedo ATM, Gouveia JJS.   +7 more
europepmc   +1 more source

Lessons from the application of implementation research (IR) to real-life policy decisions: the case study of the Ghana SAVING Consortium

Asare BA, Abassah-Konadu E, Otoo DD, Asante HA, Amankwah I, Afriyie-Twumasi A, Dalaba MA, Immurana M, Aberese-Ako M, Yevutsey S, Azeez J, Ansah E, Okorosobo T, Ogundahunsi O, Hodgson A, Gyapong M.   +15 more
europepmc   +1 more source

ASCIA Guideline: Infant Feeding for Food Allergy Prevention. [PDF]

Clin Exp Allergy
Vale SL, Netting MJ, Hornung CJ, Smith J, Roche I, McWilliam V, Hollinshead K, South C, Young A, Rueter K, Perrett KP, Palmer DJ, Joshi P, Campbell DE, Koplin JJ, Ford LS.   +15 more
europepmc   +1 more source