Results 141 to 150 of about 4,231,473 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Distribution patterns, weed incursions and origins of terrestrial flora at the Capricorn-Bunker Islands, Great Barrier Reef, Australia [PDF]

, 2013
A checklist of vascular plants of the 15 Capricorn-Bunker Islands (CBI) (lat 23° 11’ to 24° 07’S; long 151° 43’ to 152° 43’E) compiled from 2007/08 surveys, recorded 131 vascular plant species including 44 (34%) native and 87 (66%) naturalized species ...
Batianoff, George N., Naylor, Gillian C., Neldner, V. John, Olds, John   +3 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Report on the 2013 Rapid Assessment Survey of Marine Species at New England Bays and Harbors [PDF]

, 2014
Introduced species (i.e., non-native species that have become established in a new location) have increasingly been recognized as a concern as they have become more prevalent in marine and terrestrial environments (Mooney and Cleland 2001; Simberloff et ...
Cao, Yuangyu, Carlton, James T., Currimjee, Zara, Dijkstra, Jennifer A., Edquist, Sara K., Gittenberger, Arriaan, Goodnight, Seth, Grady, Sara P., Green, Lindsay A., Harris, Larry G., Harris, Leslie H., Hobbs, Niels-Viggo, Lambert, Gretchen, Pappal, Adrienne L., Pederson, Judith, Ros, Macarena, Smith, Jan P., Stefaniak, Lauren, Stevens, Alexandra, Wells, Christopher D.   +19 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Species of genus Cynoxylon Raf. introducted to Ukraine

Інтродукція Рослин, 2011
The place of genus Cynoxylon Raf. in the system of family Cornaceae Dumort., the described species introduced in Ukraine and, in particular, in M.M. Gryshko National Botanical Gardens of the NAS of Ukraine.
openaire   +2 more sources

Factors Affecting Biodiversity Protection in the Mediterranean Basin

, 2018
Earth’s biodiversity includes all extant species; however, species are not evenly distributed across the planet. Species tend to be clustered in densely populated areas known as “biodiversity hotspots;” species which inhabit only a single area are also ...
Porta, Erica L., Shircliff, Jesse E.
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Genetic diversity of Amblyomma variegatum (Acari:Ixodidae), the main vector of Ehrlichia ruminantium in Indian Ocean Islands [PDF]

, 2012
The hard ticks Amblyomma variegatum is the main vector of Ehrlichia ruminantium which is the pathogen responsible for heartwater or cowdriosis, a disease of ruminants. This tick originates from sub-Saharan Africa and is now widely widespread.
Asnaoui, M., Cardinale, Eric, Dupraz, Marlene, Girard, S., Grimaud, Yannick, Huber, Karine, Jacquet, Stéphanie, Martinez, Dominique, Stachurski, Frédéric, Vachiery, Nathalie   +9 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source