Results 71 to 80 of about 35,704 (267)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Quantum kinetic theory of metal clusters in an intense electromagnetic field

Condensed Matter Physics, 2004
A quantum kinetic theory for weakly inhomogeneous charged particle systems is derived within the framework of nonequilibrium Green's functions. The results are of relevance for valence electrons of metal clusters as well as for confined Coulomb systems ...
M.Bonitz, J.W.Dufty
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strongly-interacting mirror fermions at the LHC

EPJ Web of Conferences, 2017
The introduction of mirror fermions corresponding to an interchange of leftwith right-handed fermion quantum numbers of the Standard Model can lead to a model according to which the BEH mechanism is just an effective manifestation of a more fundamental ...
Triantaphyllou George
doaj   +1 more source

Lambda models from Chern-Simons theories

Journal of High Energy Physics, 2018
In this paper we refine and extend the results of [1], where a connection between the AdS 5 × S 5 superstring lambda model on S 1 = ∂D and a double Chern-Simons (CS) theory on D based on the Lie superalgebra p s u $$ \mathfrak{p}\mathfrak{s}\mathfrak{u} $
David M. Schmidtt
doaj   +1 more source

A Non-Technical Introduction to Confinement and N=2 Globally Supersymmetric Yang-Mills Gauge Theories [PDF]

, 1997
Francesco Fucito
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Categorical generalization of BF theory coupled to gravity

Journal of High Energy Physics
We present a thorough introduction to the tools of category theory required for formulating gauge theories based on 2-connections. We provide a detailed construction of the categorical generalization of BF theory, dubbed BFCG, also known as 2BF.
A. D. López-Hernández, Graciela Reyes-Ahumada, Javier Chagoya   +2 more
doaj   +1 more source

Lectures on Walking Technicolor, Holography, and Gauge/Gravity Dualities

Advances in High Energy Physics, 2010
Dynamical electroweak symmetry breaking is an appealing, strongly coupled alternative to the weakly coupled models based on an elementary scalar field developing a vacuum expectation value.
Maurizio Piai
doaj   +1 more source

Introduction to the Functional RG and Applications to Gauge Theories [PDF]

, 2012
Holger Gies
openalex   +1 more source