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The evolution of spliceosomal introns: patterns, puzzles and progress
Nature Reviews Genetics, 2006Scott Roy
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Introns and the origin of nucleus–cytosol compartmentalization
Nature, 2006Eugene V Koonin
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Origin of introns by ‘intronization’ of exonic sequences
Trends in Genetics, 2008The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron ...
Irimia, Manuel +5 more
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Biochemical and Biophysical Research Communications, 2005
MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. MiRNA was originally discovered in the intergenic regions of the Caenorhabditis elegans genome as native RNA fragments ...
Shao-Yao, Ying, Shi-Lung, Lin
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MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. MiRNA was originally discovered in the intergenic regions of the Caenorhabditis elegans genome as native RNA fragments ...
Shao-Yao, Ying, Shi-Lung, Lin
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Blood, 2013
In this issue of Blood, Yuan et al provide evidence that processing of the first intronic sequence within the von Willebrand factor (vWF) gene facilitates expression by endothelial cells regardless of the source of the intron, while intron processing is irrelevant for vWF expression by megakaryocytes.(1)
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In this issue of Blood, Yuan et al provide evidence that processing of the first intronic sequence within the von Willebrand factor (vWF) gene facilitates expression by endothelial cells regardless of the source of the intron, while intron processing is irrelevant for vWF expression by megakaryocytes.(1)
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Frühe Introns – späte Introns?
Biologie in unserer Zeit, 1995AbstractIntrons nennt man Nucleinsäuresequenzen, die mitten in Genregionen eingefügt sind, letztlich aber nicht in Polypeptidsequenzen übersetzt werden. Auch Prokaryoten und sogar Viren können unterbrochene Gene besitzen, aber nur bei den Eukaryoten findet man die „klassischen”︁ Introns, die dort fast alle Strukturgene zerstückeln.
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Mobile Introns and Intron-Encoded Proteins
Science, 1989P S, Perlman, R A, Butow
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Intron Biology, Focusing on Group II Introns, the Ancestors of Spliceosomal Introns
2015Self-splicing group II introns are large ribozymes and mobile retroelements initially identified in the mitochondrial and chloroplast genomes of lower eukaryotes and plants and subsequently found in bacteria and archaea. Group II introns display structural, functional and mechanistic similarities to eukaryotic pre-mRNA nuclear introns, which may have ...
María Dolores Molina-Sánchez +4 more
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Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells
Nature Biotechnology, 2022Khrystyna North +2 more
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5´-UTR introns enhance protein expression in the yeast Saccharomyces cerevisiae
Applied Microbiology and Biotechnology, 2016H. Hoshida +4 more
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