Results 131 to 140 of about 49,706 (308)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Intrusion Detection in Homogeneous and Heterogeneous Wireless Sensor Networks (WSN)
, 2013 Intrusion detection in Wireless Sensor Network (WSN) is of practical interest in many applications such as detecting an intruder in a combat zone.
P Poturaju, Srinivasaraju Dantuluri
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Artificial Intelligence-Based Intrusion Detection Techniques
, 2014 Our increasing dependence on different types of networks leads us to make them more secure. Intrusion detection is very challenging in all of those networks. An Intrusion detection system (IDS) attempts to discover malicious activities in a network. More
Jadidi, Zahra +2 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Intrusion detection issues to securing grid computing
, 2006 Traditional Intrusion Detection System (IDSs) work in isolation from access control for the application the systems aim to protect. The lack of coordination an interoperation between these components prevents detecting sophisticated attacks and ...
Dahlan, Dahliyusmanto +1 more
core
2.4-GHz (ZigBee) Indoor Intrusion Detection
, 2016 In this era of the Internet of Things, many studies have proposed and implemented smart home technologies. This paper proposes a technique that involves using link quality index level variations among end devices to detect intrusion and an algorithm for ...
Hsien-Wei Tseng; Yang-Han Lee; Yung-Wen Lee; Liang-Yu Yen
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Feature Selection Method Base on Fisher Score for Detecting SVM-Based Network Intrusions
International Journal of Information and Communication Technology Research, 2021 Mohammad Hassan Nataj Solhdar
doaj