Results 41 to 50 of about 162,879 (307)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

An overview to Software Architecture in Intrusion Detection System [PDF]

open access: yes, 2014
Today by growing network systems, security is a key feature of each network infrastructure. Network Intrusion Detection Systems (IDS) provide defense model for all security threats which are harmful to any network.
Bahrami, Mehdi, Bahrami, Mohammad
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

INTRUSION DETECTION SYSTEMS IN A HETEROGENOUS NETWORK ENVIRONMENT [PDF]

open access: yesActa Electrotechnica et Informatica, 2020
This paper deals with a design and implementation of an intrusion detection system in heterogeneous network environment. The work includes work out characteristics of Intrusion detection systems, it`s base classification, development of problematic ...
Martin ŠTANCEL   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Passive intrusion detection system [PDF]

open access: yes, 1980
An intrusion detection system is described in which crystal oscillators are used to provide a frequency which varies as a function of fluctuations of a particular environmental property of the atmosphere, e.g., humidity, in the protected volume.
Laue, E. G.
core   +1 more source

Tree-based Intelligent Intrusion Detection System in Internet of Vehicles

open access: yes, 2019
The use of autonomous vehicles (AVs) is a promising technology in Intelligent Transportation Systems (ITSs) to improve safety and driving efficiency. Vehicle-to-everything (V2X) technology enables communication among vehicles and other infrastructures ...
Hamieh, Ismail   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

CSI-based passive intrusion detection bound estimation in indoor NLoS scenario

open access: yesFundamental Research, 2023
Passive intrusion detection is important for many indoor safety applications. By utilizing widespread WiFi infrastructures, channel state information (CSI) based intrusion detection methods have attractive advantages such as low cost, non-line-of-sight ...
Linqing Gui, Wenyang Yuan, Fu Xiao
doaj   +1 more source

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