Results 51 to 60 of about 15,305 (230)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Soft-computing-based false alarm reduction for hierarchical data of intrusion detection system
International Journal of Distributed Sensor Networks, 2019 A false alarm rate of online anomaly-based intrusion detection system is a crucial concern. It is challenging to implement in the real-world scenarios when these anomalies occur sporadically.
Parminder Singh +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Research on industrial control system intrusion detection method based on simulation modelling
Tongxin xuebao, 2017 At present,intrusion detection system over fieldbus network layer was a basic protection method in industrial control system.However,it has some weakness,such as poor generality,high false-positive rate,and unable to detect unknown anomaly.An industrial ...
Yi-wei GAO +5 more
doaj +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Reinforced Intrusion Detection Using Pursuit Reinforcement Competitive Learning
Emitter: International Journal of Engineering Technology, 2014 Today, information technology is growing rapidly,all information can be obtainedmuch easier. It raises some new problems; one of them is unauthorized access to the system.
Indah Yulia Prafitaning Tiyas +3 more
doaj +3 more sources
IET Cyber-Physical SystemsSupervisory control and data acquisition systems are critical in Industry 4.0 for controlling and monitoring industrial processes. However, these systems are vulnerable to various attacks, and therefore, intelligent and robust intrusion detection systems
M. Agus Syamsul Arifin +6 more
doaj +1 more source