Results 91 to 100 of about 322,007 (344)

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

Neonatal Intubation Practice and Outcomes: An International Registry Study

Pediatrics, 2018
In this study, we report results of a novel international airway registry of endotracheal intubation in the NICU and DR settings. BACKGROUND AND OBJECTIVES: Neonatal tracheal intubation is a critical but potentially dangerous procedure.
Elizabeth E. Foglia, A. Ades, T. Sawyer, K. Glass, Neetu Singh, Philipp Jung, B. H. Quek, L. Johnston, James Barry, J. Zenge, A. Moussa, J. Kim, S. Demeo, N. Napolitano, V. Nadkarni, A. Nishisaki   +15 more
semanticscholar   +1 more source

Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study

PLoS ONE, 2020
Objective Hypotension following endotracheal intubation in the ICU is associated with poor outcomes. There is no formal prediction tool to help estimate the onset of this hemodynamic compromise. Our objective was to derive and validate a prediction model
N. Smischney, R. Kashyap, A. Khanna, E. Brauer, L. Morrow, Mohamed O. Seisa, D. Schroeder, D. Diedrich, Ashley A. Montgomery, P. M. Franco, Uchenna R. Ofoma, D. Kaufman, Ayan Sen, C. Callahan, Chakradhar Venkata, G. Demiralp, R. Tedja, Sarah Lee, M. Geube, Santhi I. Kumar, P. Morris, V. Bansal, S. Surani   +22 more
semanticscholar   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Laryngeal Injury and Upper Airway Symptoms After Oral Endotracheal Intubation With Mechanical Ventilation During Critical Care: A Systematic Review*

Critical Care Medicine, 2018
Objectives: To systematically review the symptoms and types of laryngeal injuries resulting from endotracheal intubation in mechanically ventilated patients in the ICU. Data Sources: PubMed, Embase, CINAHL, and Cochrane Library from database inception to
M. Brodsky, M. Levy, Erin Jedlanek, V. Pandian, Brendan Blackford, Carrie Price, Gai Cole, A. Hillel, S. Best, L. Akst   +9 more
semanticscholar   +1 more source

Validation of the Safe Application of Tokyo Guideline 2018 (TG18) Severity Grading and Treatment Algorithm in Super‐Elderly Patients Aged 85 and Over With Acute Cholecystitis: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background With population aging and extended healthy life expectancy, the management of acute cholecystitis (AC) in patients aged ≥ 85 years has evolved. However, the Tokyo Guidelines 2018 (TG18) for AC provide no specific risk assessment criteria for this population.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shinogu Hatano, Shojiro Hata, Hirokazu Yamaguchi   +9 more
wiley   +1 more source

Extralevator Abdominoperineal Excision Improves Overall Survival Compared to Standard Abdominoperineal Excision: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis of 38 studies, encompassing over 5000 patients, compared extralevator abdominoperineal excision (ELAPE) with standard abdominoperineal excision (APE) in patients with advanced low rectal cancer. ELAPE was associated with significantly improved overall and disease‐free survival, reduced intraoperative perforation
Sarolta Beáta Kávási, Diana‐Elena Floria, Anett Rancz, Dániel Sándor Veres, Nándor Faluhelyi, Pál Miheller, Péter Hegyi, Szabolcs Ábrahám   +7 more
wiley   +1 more source

Accidental oxygen disconnection in the emergency department

Journal of Emergencies, Trauma and Shock, 2010
Accidental oxygen disconnection during rapid sequence intubation (RSI) in the emergency department is a potentially catastrophic yet avoidable event.
Hill Guyon, Adams Bruce
doaj  

Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries.

Journal of the American Medical Association (JAMA), 2021
V. Russotto, S. Myatra, J. Laffey, E. Tassistro, L. Antolini, P. Bauer, J. Lascarrou, Konstanty Szułdrzyński, L. Camporota, P. Pelosi, M. Sorbello, A. Higgs, R. Greif, C. Putensen, Christina Agvald-Öhman, A. Chalkias, K. Bokums, D. Brewster, E. Rossi, R. Fumagalli, A. Pesenti, G. Foti, G. Bellani   +22 more
semanticscholar   +1 more source

Clinical utility of pharyngeal high‐resolution manometry with impedance for upper esophageal sphincter dysfunction in gastroenterology

Advances in Digestive Medicine, EarlyView.
Abstract Pharyngeal high‐resolution manometry with impedance (P‐HRM‐I) is an established assessment method used to evaluate pharyngeal swallowing. It provides precise quantification of swallowing biomechanics that enable the detection of alterations in swallowing physiology.
Mistyka Schar, Taher Omari, Michal Szczesniak, Chien‐Lin Chen, Richard Heddle, Charles Cock   +5 more
wiley   +1 more source