Results 181 to 190 of about 302,055 (364)

“Tension Chyle Leak”: A Life‐Threatening Sequela of Thoracic Duct Injury Following Resection of BRAF‐Mutated Anaplastic Thyroid Carcinoma

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Airway obstruction secondary to chyle leak is an exceptionally rare phenomenon. Here, we describe this complication in a patient with anaplastic thyroid carcinoma (ATC) undergoing consolidative surgery after BRAF‐targeted therapy. Methods A 55‐year‐old man presented with a rapidly enlarging neck mass.
Karim Botros   +6 more
wiley   +1 more source

Postoperative Management Following Endoscopic Skull Base Reconstruction: A Multidisciplinary Cross‐Sectional Survey

open access: yesHead &Neck, EarlyView.
ABSTRACT Background There is limited consensus on management protocols and practice patterns following endoscopic skull base surgery (ESBS). Methods An online‐based survey focusing on ESBS practice patterns was anonymously distributed to the American Rhinologic Society, North American Skull Base Society, and American Head and Neck Society Skull Base ...
Khodayar Goshtasbi   +15 more
wiley   +1 more source

Compound heterozygous loss‐of‐function variants in BRAT1 cause lethal neonatal rigidity and multifocal seizure syndrome

open access: yesMolecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
Trio‐based whole‐exome sequencing (WES) and Sanger sequencing identified a novel splicing mutation c.431‐2A>G and a heterozygous truncating mutation c.1359_1361del in BRAT1 in the proband. In addition, our research demonstrated the intronic mutation could lead to aberrant mRNA splicing and further contributed to a better understanding and establishment
Shan Li   +5 more
wiley   +1 more source

The role of human agency in nurses' hopeful career state

open access: yesHuman Resource Development Quarterly, EarlyView.
Abstract This study explores the role of human agency in shaping the hopeful career state (HCS) of nurses in Oman during the COVID‐19 pandemic. Utilizing the enhanced critical incident technique (ECIT) and integrating Albert Bandura's three modes of agency (i.e., personal, proxy, and collective), this study aimed to identify helping and hindering ...
Issa Al Balushi   +2 more
wiley   +1 more source

Role of TREM1 in the sevoflurane‐induced inflammatory activation of microglia in vitro

open access: yesIbrain, EarlyView.
Perioperative neurocognitive disorders (PNDs) are one of the most common complications in perioperative patients, and neuroinflammatory reaction mediated by microglia plays a key role in their formation. Triggering receptor expressed on myeloid cells 1 (TREM1) is a key regulator of inflammation.
Chunchun Tang   +8 more
wiley   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi   +17 more
wiley   +1 more source

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