Results 61 to 70 of about 311,400 (265)

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as Prognostic Markers of COVID-19 Disease Irrespective of Immunosuppression Status: A Case-Control Retrospective Single-Center Study

Pathogens
Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been studied as predictors for severe COVID-19 outcomes. The aim of the present study is to identify prognostic cut-off values of NLR and PLR for intubation and death in ...
Amalia Papanikolopoulou, Vasiliki Rapti, Polyxeni Alexiou, Charalampos M. Charalampous, Maria Effrosyni Livanou, Vissaria Sakka, Konstantinos N. Syrigos, Garyfallia Poulakou   +7 more
doaj   +1 more source

INTUBATION OF THE LARYNX. [PDF]

Journal of the American Medical Association, 1886
O'Dwyer's method of intubing the larynx for the cure of membranous croup being under trial, the following history of an unsuccessful case is written in order to swell the list of recorded cases from which, when large enough, we must draw our conclusions as to the efficacy of the method. On March 20 I received a note from Dr. J. B.
openaire   +2 more sources

Validation of the Safe Application of Tokyo Guideline 2018 (TG18) Severity Grading and Treatment Algorithm in Super‐Elderly Patients Aged 85 and Over With Acute Cholecystitis: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background With population aging and extended healthy life expectancy, the management of acute cholecystitis (AC) in patients aged ≥ 85 years has evolved. However, the Tokyo Guidelines 2018 (TG18) for AC provide no specific risk assessment criteria for this population.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shinogu Hatano, Shojiro Hata, Hirokazu Yamaguchi   +9 more
wiley   +1 more source

Recommendations for the management of MPS IVA: systematic evidence- and consensus-based guidance. [PDF]

, 2019
IntroductionMucopolysaccharidosis (MPS) IVA or Morquio A syndrome is an autosomal recessive lysosomal storage disorder (LSD) caused by deficiency of the N-acetylgalactosamine-6-sulfatase (GALNS) enzyme, which impairs lysosomal degradation of keratan ...
Akyol, Mehmet Umut, Alden, Tord D, Amartino, Hernan, Ashworth, Jane, Belani, Kumar, Berger, Kenneth I, Borgo, Andrea, Braunlin, Elizabeth, Eto, Yoshikatsu, Giugliani, Roberto, Gold, Jeffrey I, Harmatz, Paul, Hendriksz, Christian, Jester, Andrea, Jones, Simon A, Karsli, Cengiz, Mackenzie, William, Marinho, Diane Ruschel, McFadyen, Andrew, McGill, Jim, Mitchell, John J, MPS Consensus Programme Co-Chairs, MPS Consensus Programme Steering Committee, Muenzer, Joseph, Okuyama, Torayuki, Orchard, Paul J, Scarpa, Maurizio, Stevens, Bob, Thomas, Sophie, Walker, Robert, Wynn, Robert   +30 more
core   +2 more sources

Intubation of the larynx [PDF]

The Laryngoscope, 1900
Intubation of the larynx, which has been employed in many thousand cases in this country and abroad, has now taken its place with tracheotomy as a well-recognized procedure in the treatment of obstructive dyspnea. Before taking up the technique of the operation, I will briefly consider its history and the indications for the employment. The passing of
openaire   +3 more sources

A Soft‐Tip Hydraulically Steerable Catheter for Enhanced Flexibility and Safety in Vascular Interventions

Advanced Intelligent Systems, EarlyView.
This study introduces a hydraulically steerable catheter with a soft tip in vascular procedures. The steering soft tip achieves a minimal diameter of 2.6 mm and supports a 180° bend. Real‐time shape and position tracking, facilitated by segmentation and endpoint detection techniques, improves navigation.
Jingyi Kang, Ye Wang, Jiayuan Liu, Zhuhao Wang, Xuan Yang, Jie Wang, Jian Wu, Guochen Ning, Boyu Zhang, Hongen Liao   +9 more
wiley   +1 more source

Exogenous lipoid pneumonia due to medical aspiration of paraffin oil: a case report and literature review

Frontiers in Medicine
This case report describes a case of exogenous lipoid pneumonia (ELP) due to medical aspiration of paraffin oil. An 87-year-old male was hospitalized with bedridden, dysphagic dysphagia.
Mingshuang Li, Mingshuang Li, Conglin Ren, Conglin Ren, Cangsong Chen, Cangsong Chen   +5 more
doaj   +1 more source

Hemodynamic response to tracheal intubation in postlaryngectomy patients

Journal of Anaesthesiology Clinical Pharmacology, 2019
Background and Aims: Endotracheal intubation in postlaryngectomy patients is usually accomplished by inserting endotracheal tube directly into the laryngectomy stoma.
Sunil Rajan, Rajvignesh Chandramohan, Jerry Paul, Lakshmi Kumar   +3 more
doaj   +1 more source

A “Principled Resolution”: The Fulcrum for Bioethics Mediation [PDF]

, 2011
The concept of a principled resolution is the foundation for bioethics mediation. Dubler presents the core bioethical principles that support the creation of principled resolutions as fulcrums for resolving disagreements in the healthcare setting ...
Dubler, Nancy Neveloff
core   +1 more source