TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Control Strategies in Guanine Biocrystallization
Angewandte Chemie, EarlyView.Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri +2 more
wiley +2 more sources
Double Intussusception in a Shih-Tzu Puppy: The Triple-Circle Sign [PDF]
Pakistan Veterinary Journal, 2012 Intussusception is a common surgical disorder in puppies. Double intussusception (DI) however, is an extremely rare form of this pathology. The authors report a case of a 3-month-old, Shih-Tzu puppy referred to Veterinary Medical Center of Chungbuk ...
J. M. Kim, S. S. Kang1, G. Kim and S. H. Choi*
doaj
Evaluating the Surgeons' Perception of Difficulties of Two Techniques to Perform STARR for Obstructed Defecation Syndrome: A Multicenter Randomized Trial. [PDF]
, 2016 BACKGROUND After initial enthusiasm in the use of a dedicated curved stapler (CCS-30 Contour Transtar) to perform stapled transanal rectal resection (STARR) for obstructed defecation syndrome (ODS), difficulties have emerged in this surgical technique.
Adolfo Renzi, Md +11 more
core +1 more source
Long-Term Functional Outcome after Internal Delorme's Procedure for Obstructed Defecation Syndrome, and the Role of Postoperative Rehabilitation [PDF]
, 2017 PURPOSE: To evaluate long-term functional outcomes of Internal Delorme's Procedure (IDP) in patients refractory to conservative treatment for Obstructed Defecation Syndrome (ODS), and to compare those who received postoperative rehabilitation with those ...
Campenn\uec, P +9 more
core +1 more source
A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients [PDF]
, 2011 Background Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips, and an increased risk of developing cancer.
Zhiqing Wang +5 more
core +1 more source
Skin Signs of Systemic Disease [PDF]
, 1976 The subject of this Mcguire Lecture series, the skin, is a relatively enormous organ vulnerable to an enormous variety of external and internal insults. Its total visibility is both a blessing and a curse.
Scoggins, Robert B.
core +2 more sources
Chronic Idiopathic Intestinal Pseudo-Obstruction: A Working Diagnosis [PDF]
, 2015 Introduction Chronic intestinal pseudo-obstruction (CIP) is a rare and disabling motility syndrome, yet one that demands an extensive review of digestive motility and peristaltic pathophysiology. Primarily a disorder of the small intestine, CIP was first
Dimarino, MD, Anthony, Kalra, MD, Ankush
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PTEN hamartoma tumor syndromes in childhood: description of two cases and a proposal for follow-up protocol [PDF]
, 2013 PTEN hamartoma tumor syndromes (PHTS) are a spectrum of hamartomatous overgrowth syndromes associated with germline mutations in the tumor suppressor PTEN gene located on 10q23.3.
Antona, V +5 more
core +1 more source
Food for thought : palatable eponyms from Pediatrics [PDF]
, 2014 Food-related medical terms are frequently used in the field of pediatrics for the definition, recognition and diagnosis of disease. Almost 40 food-related medical eponyms used in Pediatrics have been ‘cherry picked’ and described by the authors.
Kipersztok, Lisa, Masukume, Gwinyai
core