Results 201 to 210 of about 4,377,369 (241)

Examining Neuromuscular and Cortical Activity Over 1 Year Following Anterior Cruciate Ligament Reconstruction. [PDF]

Scand J Med Sci Sports
Busch A, Mayer F, Baur H.
europepmc   +1 more source

Envonalkib Versus Crizotinib in Treatment‐Naive ALK‐Positive Non‐Small Cell Lung Cancer: Final Efficacy and Biomarker Analyses of the Randomized Phase III Study

MedComm, Volume 7, Issue 10, October 2026.
Envonalkib provides robust and durable benefit in treatment‐naïve ALK‐positive NSCLC, with median PFS of 30.4 months versus 12.0 months for crizotinib. Exploratory biomarker analyses showed that concurrent driver alterations and p53 pathway dysfunction reduce treatment efficacy.
Jie Huang, Yuanyuan Wang, Haishuang Sun, Jie Min, Nong Yang, Qitao Yu, Ying Cheng, Yanqiu Zhao, Manxiang Li, Hong Chen, Shouan Ren, Jianying Zhou, Wu Zhuang, Xintian Qin, Lejie Cao, Yan Yu, Jian Zhang, Jianxing He, Jifeng Feng, Hao Yu, Lin Zhang, Xinyuan Zhao, Wenfeng Fang, Jing Li, Li Zhang, Yunpeng Yang   +25 more
wiley   +1 more source

Design, control, and computational validation of a mechanically decoupled 3-DOF ankle rehabilitation device. [PDF]

Sci Rep
ElSherbini AI, Sameh A, Ali S, Khalil AT.   +3 more
europepmc   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Genomic surveillance reveals co-occurrence of Plasmodium falciparum drug resistance variants across diverse transmission settings in Ethiopia. [PDF]

Nat Microbiol
Letebo A, Vanheer LN, Engdaw M, Ejigu LA, Hailu Alemayehu D, Deressa JD, Adnew B, Ayele A, Bezabih MK, Demisse M, Seyoum T, Shiferaw M, Sime H, Weldemariam AG, Shimelash A, Tafa EB, Chali W, Alemayehu L, Kassa FA, Zeleke AJ, Hamza TA, Tamirat AB, Misganaw T, Bogale A, Abriham ZY, Nasir Y, Jebessa G, Yohannes M, Kebede BA, Ayele MK, Abdo M, Habtamu G, Gizat A, Phelan J, Matlock B, Fidock DA, Campino S, Assefa A, Koepfli C, Massebo F, Tadesse FG.   +40 more
europepmc   +1 more source

1H HR‐MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Metabolomic profiling of breast cancer tissue using 1H HR‐MAS NMR spectroscopy and LCModel‐based quantitative analysis revealed metabolite differences associated with immunohistochemical subtypes, and subsequent metabolomics–transcriptomics integration linked these subtype‐dependent metabolic signatures to pathways in choline metabolism, one‐carbon ...
Irene Garcia‐Bocanegra, Jesus David Urbano‐Gamez, Antonio Perez‐Cardona, Laura Barrios, Maria Isabel Somoza‐Ramírez, Luis Vicioso, Elena Pardo‐Susacasa, Gema Diaz‐Cordoba, Maria Mercedes Acebal‐Blanco, Francisco Sendra‐Portero, Maria Luisa Garcia‐Martin   +10 more
wiley   +1 more source

Robust Performance Loss Rate Calculation for Photovoltaic Systems in High Latitude Locations

Progress in Photovoltaics: Research and Applications, Volume 34, Issue 10, Page 1256-1276, October 2026.
This work studies the best methods for performance loss rate (PLR) calculation in high latitude locations, characterized by strong seasonal variability. As the different methods can drastically affect the PLR value, an ensemble method consisting of multiple approaches was validated to be essential in identifying robust PLRs.
Lauri Karttunen, Väinö Anttalainen, Sami Jouttijärvi, Juha A. Karhu, Hugo Huerta, Samuli Ranta, Anders V. Lindfors, Kati Miettunen   +7 more
wiley   +1 more source

Application of Cobas 6800 HPV testing and qPCR utilizing three genomically-optimized primer sets for detecting HPV DNA in the blood of HPV Positive dysplasia and cancer patients. [PDF]

PLoS One
Mostafa HH, Fall A, Gaillard S, Fakhry C, Khan Z, Seiwert T, Wang H, Tsai HL, Fader AN, Leath CA, Huh WK, Arend RC, Tsai YC, Califano JA, Xing D, Wu TC, Roden RBS.   +16 more
europepmc   +1 more source

Development, Early Verification and Application of a North American Pediatric PBPK Model, Comparison With the North European Pediatric Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) models are increasingly used in pediatric drug development and matching such models to the target population is an important consideration. A US pediatric PBPK model was developed incorporating four sub‐groups describing physiology and enzymatic/transporter levels for White, African American ...
Trevor N. Johnson, Fiskani Kondowe, Joyce van der Heijden, Saskia N. de Wildt, Iain Gardner, Karen Rowland Yeo   +5 more
wiley   +1 more source

Rewiring mitochondrial phosphatidylethanolamine metabolism identifies new and unaccounted trafficking steps. [PDF]

J Lipid Res
Prem R, Avery E, Marquez JM, Xie C, Claypool SM.   +4 more
europepmc   +1 more source