Results 141 to 150 of about 76,132 (306)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Optimal Demand for Contingent Claims when Agents have law Invariant Utilities. [PDF]

We consider a class of law invariant utilities which contains the Rank Dependent Expected Utility (RDU) and the cumulative prospect theory (CPT). We show that the computation of demand for a contingent claim when utilities are within that class, although
Carlier, Guillaume, Dana, Rose-Anne
core  

Invariant measures for multilane exclusion process

, 2021
74 pagesWe consider the simple exclusion process on Z × {0, 1}, that is, an "horizontal ladder" composed of 2 lanes, depending on 6 parameters. Particles can jump according to a lane-dependent translation-invariant nearest neighbour jump kernel, i.e ...
Amir, Gidi, Amir, Gideon, Saada, Ellen, Bahadoran, Christophe, Busani, Ofer   +4 more
core  

A scalable approach to the computation of invariant measures for high-dimensional Markovian systems. [PDF]

Sci Rep, 2018
Gerber S, Olsson S, Noé F, Horenko I.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Invariant Measures for Hybrid Stochastic Systems

, 2014
In this paper, we seek to understand the behavior of dynamical sys-tems that are perturbed by a parameter that changes discretely in time. If we impose certain conditions, we can study certain embedded systems within a hybrid system as time-homogeneous ...
Thomas Rudelius, Sijing Shao, Emily Speranza, Anthony Sanchez, Xavier Garcia, Jennifer Kunze   +5 more
core  

On invariant probability measures I [PDF]

Pacific Journal of Mathematics, 1960
Blum, J. R., Hanson, D. L.
openaire   +5 more sources

The Second Maximum Mostar Index of Unicyclic Graphs With Given Diameter

Journal of Mathematics
Topological invariants are key tools for studying the physicochemical and thermodynamic properties of chemical compounds. Recently, a new bond-additive distance-based graph invariant called the Mostar index has been developed.
Muhammad Amer Qureshi, Asad Ullah, Parvez Ali, Emad E. Mahmoud, Melaku Berhe Belay   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source