Results 131 to 140 of about 43,265 (297)

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Invasion Science and the Global Spread of SARS-CoV-2. [PDF]

open access: yesTrends Ecol Evol, 2020
Nuñez MA, Pauchard A, Ricciardi A.
europepmc   +1 more source

Notas sobre Neófitos en el curso urbano del río Guadalquivir en Sevilla [PDF]

open access: yes, 2010
El asentamiento y expansión de especies vegetales en regiones fuera de su área de distribución natural por causas antrópicas, es uno de los problemas más importantes que afectan a la conservación de la biodiversidad. Las especies alóctonas suponen una
Escudero Lirio, Marcial   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Coup d’Etat express au Paraguay. Démocratie et représentation [PDF]

open access: yes, 2012
La nouvelle de l'ouverture d'une procédure d'impeachment contre le président paraguayen Fernando Lugo a pris par surprise les chefs d'Etat sud-américains qui participaient au sommet Rio+20. Et avant même qu'ils aient le temps de réagir, le Congrès votait
Dabène, Olivier
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

LA CONSERVACIÓN BIOLÓGICA Y SU PERSPECTIVA EVOLUTIVA

open access: yesActa Biológica Colombiana, 2009
RESUMEN Este artículo revisa dos de las principales causas de amenaza a la diversidad biológica, como son la fragmentación y/o pérdida del hábitat y la introducción e invasión de especies exóticas, principalmente en lo que compete a sus implicaciones ...
Olga Montenegro
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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