Results 181 to 190 of about 43,265 (297)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Listening Deeply to Indigenous People: A Collaborative Perspective and Reflection Between a Mapuche Machi and Ecologists. [PDF]

Ecol Evol
Ortiz AMD, Huinca Blanco P, Arnillas CA, Arponen A, Cadotte MW, Chinga JB, Chiuffo MC, Collinge S, Devarajan K, Ehrlich K, Grell-Brisk M, Guevara C, Kariuki RW, Kharouba HM, Martin TG, Prado-Valladares AC, Prado-Valladares AC, Regan HM, Santos Domínguez N, Soares BE, Stotz GC, Ulloa Caniú I, Visakorpi K, Winter M, Yannelli FA.   +24 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Preliminary assessment of seed heteromorfism as an adaptive strategy of Colobanthus quitensis under saline conditions. [PDF]

Sci Rep
Ontivero Y, Fuentes-Lillo E, Navarrete-Campos D, Vázquez-Villa D, Cabreras-Barjas G, Arroyo-Marín FB, Cuba-Díaz M.   +6 more
europepmc   +1 more source

Erosion of global functional diversity across the tree of life. [PDF]

Sci Adv, 2021
Carmona CP, Tamme R, Pärtel M, de Bello F, Brosse S, Capdevila P, González-M R, González-Suárez M, Salguero-Gómez R, Vásquez-Valderrama M, Toussaint A.   +10 more
europepmc   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Instruments and agents of control: smallpox in the Río de la Plata at the beginning of the nineteenth century. [PDF]

Hist Cienc Saude Manguinhos
Liscia MSD.
europepmc   +1 more source

Biodiversity assessments: Origin matters. [PDF]

PLoS Biol, 2018
Pauchard A, Meyerson LA, Bacher S, Blackburn TM, Brundu G, Cadotte MW, Courchamp F, Essl F, Genovesi P, Haider S, Holmes ND, Hulme PE, Jeschke JM, Lockwood JL, Novoa A, Nuñez MA, Peltzer DA, Pyšek P, Richardson DM, Simberloff D, Smith K, van Wilgen BW, Vilà M, Wilson JRU, Winter M, Zenni RD.   +25 more
europepmc   +1 more source