Results 131 to 140 of about 393,600 (259)

The Complement System in ANCA‐Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Kehinde Sunmboye, Pauline Millan
wiley   +1 more source

Serogroup C Neisseria meningitidis disease epidemiology, seroprevalence, vaccine effectiveness and waning immunity, England, 1998/99 to 2015/16. [PDF]

, 2019
Background In 1999, the United Kingdom (UK) was the first country to introduce meningococcal group C (MenC) conjugate vaccination. This vaccination programme has evolved with further understanding, new vaccines and changing disease epidemiology.
Bazan, Borrow, Campbell, Farrington, Folaranmi, Gray, Hill, Hill, Huson, Ishola, Jolley, Kupferschmidt, Ladhani, Ladhani, Lucidarme, Lucidarme, Maiden, Maslanka, Miglietta, Miller, Neal, Nunes, Osborne, Parent du Chatelet, Ramsay, Simmons, Stoof, Sáfadi, Taha, Trotter, Trotter, Tzeng, Whittaker   +32 more
core   +1 more source

Influenza increases invasive meningococcal disease risk in temperate countries.

Clinical Microbiology and Infection, 2020
OBJECTIVES Invasive meningococcal disease (IMD) is a severe bacterial infection that displays wintertime seasonality in temperate countries. Mechanisms driving seasonality are poorly understood and may include environmental conditions and/or respiratory ...
A. Salomon, I. Berry, A. Tuite, S. Drews, T. Hatchette, F. Jamieson, Caroline C. Johnson, J. Kwong, B. Lina, J. Lojo, A. Mosnier, V. Ng, P. Vanhems, D. Fisman   +13 more
semanticscholar   +1 more source

Brain Abscesses Complicating Bacterial Meningitis—A Nationwide Cohort Study From the Netherlands

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Prevalence, pathogen distribution, clinical characteristics, and outcomes of brain abscess in bacterial meningitis was assessed in this study. ABSTRACT Background Brain abscesses rarely complicate bacterial meningitis while their clinical characteristics and outcomes have not been systematically assessed.
Fabian D. Liechti, Evelien H. G. M. Drost, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek   +4 more
wiley   +1 more source

Novel hypercapsulation RNA thermosensor variants in Neisseria meningitidis and their association with invasive meningococcal disease: a genetic and phenotypic investigation and molecular epidemiological study

The Lancet Microbe, 2020
Summary: Background: Neisseria meningitidis is the causative agent of invasive meningococcal disease and the polysaccharide capsule is one of its major virulence factors.
Jens Karlsson, MSc, Hannes Eichner, MSc, Cecilia Andersson, BSc, Susanne Jacobsson, PhD, Edmund Loh, PhD   +4 more
doaj   +1 more source

Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study. [PDF]

, 2019
BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease.
Andrews, N, Carreras-Abad, C, Cochet, M, Djennad, A, Hall, T, Hamid, R, Heath, P, Khalil, A, Le Doare, K, Peregrine, E, Planche, T, Plumb, J, Ramkhelawon, L, Sheridan, E, Sivarajan, S, Vinayakarao, L, Winchester, S   +16 more
core   +1 more source

Clinical and economic burden of invasive meningococcal disease: Evidence from a large German claims database

PLoS ONE, 2020
Background Limited data is available to describe clinical characteristics, long-term outcomes, healthcare resource use and the attributable costs of invasive meningococcal disease (IMD) in Germany.
Liping Huang, Olivia Denise Heuer, Sabrina Janßen, Dennis Häckl, N. Schmedt   +4 more
semanticscholar   +1 more source

Laparoscopic Partial Splenectomy for a Giant Congenital Splenic Cyst in a Child: Case Report and Focused Literature Review

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT An 11‐year‐old boy with a 16 × 14.5 cm congenital splenic cyst underwent laparoscopic upper‐pole partial splenectomy after negative hydatid workup and vaccination. Recovery was uneventful; histology confirmed epithelial cyst. Spleen‐preserving surgery provided durable symptom relief and preserved function.
Ahmed Alanzi, Dawood Alatefi, Malik Alkabazi, Bano Alsaleh, Khaled M. AlAani, Samah Hakmi   +5 more
wiley   +1 more source

Emergence and genomic diversification of a virulent serogroup W:ST-2881(CC175) Neisseria meningitidis clone in the African meningitis belt. [PDF]

, 2017
Countries of the African 'meningitis belt' are susceptible to meningococcal meningitis outbreaks. While in the past major epidemics have been primarily caused by serogroup A meningococci, W strains are currently responsible for most of the cases.
Abdul Sater, Mohamad R, Bentley, Stephen D, Dangy, Jean-Pierre, Hamid, Abdul-Wahab M, Harris, Simon R, Hauser, Julia, Hodgson, Abraham, Junghanss, Thomas, Lamelas, Araceli, Parkhill, Julian, Pluschke, Gerd, Röltgen, Katharina, Sie, Ali   +12 more
core   +1 more source

Atypical presentation of invasive meningococcal disease caused by serogroup W meningococci

Epidemiology and Infection, 2020
Neisseria meningitidis, a gram-negative diplococcus, is typically an asymptomatic coloniser of the oropharynx and nasopharynx. Passage of N. meningitidis into the bloodstream can cause invasive meningococcal disease (IMD), a potentially life-threatening ...
C. Stinson, C. Burman, Jessica Presa, M. Abalos   +3 more
semanticscholar   +1 more source