Results 61 to 70 of about 355,625 (242)

Occupationally Relevant Zinc‐ and Copper‐Containing Metal Fumes Inhibit Human THP‐1 Macrophage TNF and IL‐6 Responses to Bacterial Stimuli

Global Challenges, Volume 9, Issue 5, May 2025.
Metal workers have an increased risk of severe pneumonia due to metal fume exposure. In this study, zinc oxide (ZnO) and copper oxide (CuO) particles are found to inhibit specific anti‐bacterial macrophage responses, which may substantially contribute to impaired lung immunity.
Jan Steffens, Sabrina Michael, Katharina Kuth, Henner Hollert, Miriam Du Marchie Sarvaas, Andrijana Nesic, Thomas Kraus, Ralf Baumann   +7 more
wiley   +1 more source

Changes in the incidence, viral coinfection pattern and outcomes of pneumococcal hospitalizations during and after the COVID-19 pandemic

Pneumonia
Background The incidence of pneumococcal pneumonia in the context of the Coronavirus Disease 2019 (COVID-19) pandemic, along with the real-world data on the ratio of non-invasive to invasive pneumococcal pneumonia, is an area that has not been thoroughly
King-Pui Florence Chan, Ting-Fung Ma, Hanshu Fang, Wai-Kai Tsui, James Chung-Man Ho, Mary Sau-Man Ip, Pak-Leung Ho   +6 more
doaj   +1 more source

Risk of invasive pneumococcal disease in children with sickle cell disease in the era of conjugate vaccines: a systematic review of the literature

British Journal of Haematology, 2019
Pneumococcal conjugate vaccines (PCVs) are highly effective in preventing invasive pneumococcal diseases (IPD) in children, including those with sickle cell disease (SCD).
G. Oligbu, M. Fallaha, L. Pay, S. Ladhani   +3 more
semanticscholar   +1 more source

Mathematical modelling of cancer invasion: Phenotypic transitioning provides insight into multifocal foci formation [PDF]

arXiv, 2023
The transition from the epithelial to mesenchymal phenotype and its reverse (from mesenchymal to epithelial) are crucial processes necessary for the progression and spread of cancer. In this paper, we investigate how phenotypic switching at the cancer cell level impacts on behaviour at the tissue level, specifically on the emergence of isolated foci of
arxiv  

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Preventive measures in infancy to reduce under-five mortality: a case-control study in The Gambia.

, 2009
OBJECTIVE: To investigate the relationship between child mortality and common preventive interventions: vaccination, trained birthing attendants, tetanus toxoid during pregnancy, breastfeeding and vitamin A supplementation. METHODS: Case-control study in
Adegbola, Richard A, Dockerty, John D, Herbison, Peter, Hill, Philip C, Howie, Stephen RC, Jasseh, Momodou, Jeffries, David J, Mulholland, Kim, Rutherford, Merrin E   +8 more
core   +1 more source

Nasopharyngeal Microbiota in Children With Invasive Pneumococcal Disease: Identification of Bacteria With Potential Disease-Promoting and Protective Effects

Frontiers in Microbiology, 2019
Background and Aims: The risk of suffering from some infectious diseases can be related to specific microbiota profiles. Specifically, the nasopharyngeal microbiota could play a role as a risk or protective factor in the development of invasive disease ...
A. Camelo-Castillo, D. Henares, P. Brotons, A. Galiana, J. C. Rodríguez, A. Mira, C. Muñoz-Almagro   +6 more
semanticscholar   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Comparison of the Impact of Pneumococcal Conjugate Vaccine 10 or Pneumococcal Conjugate Vaccine 13 on Invasive Pneumococcal Disease in Equivalent Populations

Clinical Infectious Diseases, 2017
Background Pneumococccal conjugated pneumococcal vaccine (PCV10) and pneumococcal conjugate vaccine 13 (PCV13), are used in childhood immunization programs worldwide, but direct comparisons of impacts against invasive pneumococcal disease (IPD) in ...
P. Nauclér, I. Galanis, E. Morfeldt, J. Darenberg, Å. Örtqvist, B. Henriques-Normark   +5 more
semanticscholar   +1 more source

Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia

Aging Cell, Volume 24, Issue 5, May 2025.
During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu, Tianmou Zhu, Hongmei Mou, Shumin Tan, John M. Leong   +4 more
wiley   +1 more source