Advanced Science, EarlyView.ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao +12 more
wiley +1 more source
Intrinsic PPG–ECG Coupling for Accurate and Low‐Power Blood Pressure Monitoring
Advanced Science, EarlyView.A PPG–ECG coupling strategy for continuous blood pressure monitoring that intrinsically synchronizes signals within a single waveform is demonstrated, minimizing synchronization errors and hardware complexity. This approach halves power consumption while maintaining high accuracy, enabling compact, energy‐efficient wearable devices for personalized ...
Sitong Chen +5 more
wiley +1 more source
Spatial genetic structure of the invasive tree Robinia pseudoacacia to determine migration patterns to inform best practices for riparian restoration. [PDF]
AoB Plants, 2020 Yaegashi S, Omura T, Watanabe K.
europepmc +1 more source
Crommet Creek Conservation Area Management Plan [PDF]
, 2012 The Crommet Creek Conservation Area comprises the largest block of natural lands in the immediate Great Bay watershed, and in New Hampshire’s North Atlantic Coast Ecoregion. It includes the entire watershed of two tidal creeks that flow directly into the
Brickner-Wood, Dea +5 more
core +2 more sources
Advanced Science, EarlyView.A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding +6 more
wiley +1 more source
Increased soil moisture aggravated the competitive effects of the invasive tree Rhus typhina on the native tree Cotinus coggygria. [PDF]
BMC Ecol, 2020 Guo X +5 more
europepmc +1 more source
Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency
Advanced Science, EarlyView.Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu +23 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin +5 more
wiley +1 more source
Oral Ingestion of Bacterially Expressed dsRNA Can Silence Genes and Cause Mortality in a Highly Invasive, Tree-Killing Pest, the Emerald Ash Borer. [PDF]
Insects, 2020 Leelesh RS, Rieske LK.
europepmc +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source