Results 61 to 70 of about 199,674 (267)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Invasive neurostimulation [PDF]

The Journal of Headache and Pain, 2015
Chronic migraine afflicts 1-5% of the global population and poses a substantial burden on subjects’ quality of life and on health services utilization [1]. Although most patients benefit from abortive and preventive drugs, a subgroup of patients remains refractory to treatment. Refractory chronic migraine is one of the greatest chal- lenges in headache
MERCIERI, MARCO, ARCIONI, Roberto, PALMISANI, STEFANO, VANO, VALENTINA, TIGANO, SARA, Smith, Thomas, DEL FIORE, MARIA ROSARIA, SILVESTRI, BARBARA, Al Kaisy, Adnan, MARTELLETTI, Paolo   +9 more
openaire   +3 more sources

The Tropical Seagrass Halophila stipulacea: Reviewing What We Know From Its Native and Invasive Habitats, Alongside Identifying Knowledge Gaps

Frontiers in Marine Science, 2020
Halophila stipulacea is a small tropical seagrass, native to the Red Sea, Persian Gulf, and the Indian Ocean. It invaded the Mediterranean Sea 150 years ago as a Lessepsian migrant, but so far has remained in insulated, small populations across this ...
Gidon Winters, Gidon Winters, Sven Beer, Demian A. Willette, Inés G. Viana, Inés G. Viana, Kelcie L. Chiquillo, Pedro Beca-Carretero, Betty Villamayor, Tomás Azcárate-García, Tomás Azcárate-García, Rachamim Shem-Tov, Bridget Mwabvu, Luciana Migliore, Alice Rotini, Michelle A. Oscar, Michelle A. Oscar, Jonathan Belmaker, Jonathan Belmaker, Inbal Gamliel, Ana Alexandre, Aschwin H. Engelen, Gabriele Procaccini, Gil Rilov   +23 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Elastin molecular aging promotes MDA‐MB‐231 breast cancer cell invasiveness

FEBS Open Bio, 2018
Elastin is a long‐lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of ...
Stéphanie Salesse, Ludivine Odoul, Lise Chazée, Christian Garbar, Laurent Duca, Laurent Martiny, Rachid Mahmoudi, Laurent Debelle   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion

International Journal of Nanomedicine, 2017
Mateusz Wierzbicki,1 Sławomir Jaworski,1 Marta Kutwin,1 Marta Grodzik,1 Barbara Strojny,1 Natalia Kurantowicz,1 Krzysztof Zdunek,2 Rafał Chodun,2 André Chwalibog,3 Ewa Sawosz1 1Division of Nanobiotechnology, Warsaw University of Life Science ...
Wierzbicki M, Jaworski S, Kutwin M, Grodzik M, Strojny B, Kurantowicz N, Zdunek K, Chodun R, Chwalibog A, Sawosz E   +9 more
doaj