Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Protective device in cardiopulmonary resuscitation with its hand positioning barrier device of international class: A61H/31/00. [PDF]
Am Heart J PlusTavan H.
europepmc +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Patent Landscape of Fiber-Based Fabrication Technologies for Functional Biomaterials: Electrospinning, Forcespinning® and Melt Electrowriting in Tissue Engineering and Drug Delivery (2020 to 2024). [PDF]
J Funct BiomaterSattler AM +3 more
europepmc +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
A Multimodal Multitask Artificial Intelligence Model for Orthokeratology Contact Lens Fitting: An Integrated Framework to Enhance Lens Centration and Myopia Control Effect. [PDF]
Ophthalmol SciZhang Z, Zhou X, Li C, Xiao Y, Chen Z.
europepmc +1 more source
Invention before theory: how the practical often leads theory
Jose Marinez, Lizbeth Goodman
openalex +1 more source