Results 151 to 160 of about 52,986 (288)

Dos provérbios ao conhecimento científico: de poeta e cientista inventor todos temos um pouco com algum labor – o ensino das ciências físicas e naturais no 1.º e 2.º ciclos do ensino básico

, 2019
Joana Rocha, Xana Sá‐Pinto, Alexandre Pinto, José António Gomes, Elisama Sousa de Oliveira   +4 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Design and Fabrication of Customised Diabetic Insoles for Optimised Foot Pressure Distribution Using Finite Element Analysis and Additive Manufacturing Technology. [PDF]

Bioengineering (Basel)
Mala J, Bisheh H.
europepmc   +1 more source

An Ethnography of Women Inventors in Chicago

, 1992
Christine E. Lachman
openalex   +1 more source

Implementation of Android-Based Electrical Energy Monitoring and Power Factor Improvement Using MIT App Inventor and Firebase

Andre Rabiula, Dasrinal Tessal, Aldy Pratama, Togi SiholMarito Simarmata, Elsa Lolita Anggraini, Illa Aryeni   +5 more
openalex   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Why We Should Recognize AI as an Inventor. [PDF]

J Bioeth Inq
Bayındır AS, Danaher J.
europepmc   +1 more source

Business Method Patents, Franchises, and the First Inventor Defense Act: Something Must Give

, 2001
Matthew D. Thayne
openalex   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Leonardo da Vinci's depiction of the liver. [PDF]

Hepatobiliary Surg Nutr
van Gulik TM.
europepmc   +1 more source