Results 31 to 40 of about 275,657 (308)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Deep Controlled Learning for Inventory Control

open access: yesEuropean Journal of Operational Research
The application of Deep Reinforcement Learning (DRL) to inventory management is an emerging field. However, traditional DRL algorithms, originally developed for diverse domains such as game-playing and robotics, may not be well-suited for the specific challenges posed by inventory management.
Tarkan Temizöz   +4 more
openaire   +4 more sources

Forecasting and inventory control for hospital management [PDF]

open access: yes, 1977
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.Economic stringencies have compelled Canadian hospitals to examine their administrative effectiveness critically.
Crowe, Walter Ramsey   +1 more
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

The influence of inventory sequencing for the improvement of inventory control: Evidence from a South African automotive assembly organisation

open access: yesActa Commercii, 2020
Orientation: Control of inventory is a central issue in operations management and has received a considerable amount of attention in literatures. One of the reasons behind this attention is that inventory holding comprises a significant cost in the ...
Robert W.D. Zondo
doaj   +1 more source

Linear integrated location-inventory models for service parts logistics network design [PDF]

open access: yes, 2013
We present two integrated network design and inventory control problems in service-parts logistics systems. Such models are complicated due to demand uncertainty and highly nonlinear time-based service level constraints.
Nematollahi, Eissa   +2 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Neuro-dynamic programming for cooperative inventory control [PDF]

open access: yes, 2004
In Multi-Retailer Inventory Control the possibility of sharing set up costs motivates communication and coordination among the retailers. We solve the problem of finding suboptimal distributed reordering policies which minimize set up, ordering, storage ...
Bauso D.   +12 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Accelerate demand forecasting by hybridizing CatBoost with the dingo optimization algorithm to support supply chain conceptual framework precisely

open access: yesFrontiers in Sustainability
Supply chains (SCs) serve many sectors that are, in turn, affected by e-commerce which rely on the make-to-order (MTO) system to avoid a risk in following the make-to-stoke (MTS) policy due to poor forecasting demand, which will be difficult if the ...
Ahmed M. Abed, Ahmed M. Abed
doaj   +1 more source

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