Results 81 to 90 of about 142 (134)
ABSTRACT Multi‐supported non‐structural components (NSCs) are prone to seismic damage, yet their response prediction remains challenging when support motions are spatially incoherent. This study proposes an enhanced quasi‐static condensation (EQSC) method for linear, lightweight, dynamically detuned multi‐supported NSCs under the neglect of primary ...
Duozhi Wang +5 more
wiley +1 more source
FDM‐fabricated PA12 thin‐walled tubes with five hexagonal architected designs (D1–D5) of increasing nodal connectivity were investigated to determine the effects of wall architecture, layer height, and print angle orientation on compressive performance, energy absorption, and dimensional accuracy.
Vigneshwaran Karupaiah +4 more
wiley +1 more source
SIRT Family: Biological Functions and Therapeutic Targets
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang +9 more
wiley +1 more source
Lymphatic Endothelial Cells in Health and Disease
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang +5 more
wiley +1 more source
Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei +9 more
wiley +1 more source
ABSTRACT Numerical simulation of hydraulic fracturing remains challenging due to the strong coupling between geomechanics and fluid flow when modelling multiple physical mechanisms of rock deformation, fracture evolution and fluid leak‐off. This study develops a coupled hydraulic fracture propagation framework that combines the extended finite element ...
Ran Tao, Juliana Y. Leung, Samer Adeeb
wiley +1 more source
ABSTRACT An efficient semi‐analytical approach based on the Fourier–Bessel series (FBS) system of vector functions and the stiffness matrix method is proposed to study the dynamic response of axially loaded piles embedded in transversely isotropic (TI) layered soil.
Quoc Kinh Tran +5 more
wiley +1 more source
Abstract We develop a sensitivity‐guided, surrogate‐assisted Bayesian framework to infer fracture network parameters from elastic waves. Synthetic fracture networks characterized by power‐law length exponent a $a$, fracture density d $d$, and percolation parameter p $p$ are constructed.
Le Zhang +4 more
wiley +1 more source
Active Tectonics of the Eastern and Southern Alps ‐ Crustal Response to Deep Processes? A Review
Abstract Owing to the low N‐S convergence rates between Adria and Europe, crustal deformation rates in the Alps and its forelands are low. Active tectonics are, therefore, difficult to study, especially as non‐tectonic landscape forming processes can erase or modify the tectonic surface imprint. Large‐scale and dense seismological data recently offered
Christoph Grützner +20 more
wiley +1 more source
Neural‐Initialized Newton: Accelerating Nonlinear Finite Elements via Operator Learning
ABSTRACT We propose a Newton‐based scheme, initialized by neural operator predictions, to accelerate the parametric solution of nonlinear problems in computational solid mechanics. First, a physics‐informed neural operator based on conditional neural fields or Fourier neural operators is trained to approximate the nonlinear parametric solution of the ...
Kianoosh Taghikhani +5 more
wiley +1 more source

