Results 51 to 60 of about 1,119,291 (284)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Hybrid Method for Inverse Elastic Obstacle Scattering Problems

open access: yesMathematics, 2023
The problem of determining the shape of an object from knowledge of the far-field of a single incident wave in two-dimensional elasticity was considered. We applied an iterative hybrid method to tackle this problem. An advantage of this method is that it
Yuhan Yin, Juan Liu
doaj   +1 more source

DIRECT AND INVERSE ACOUSTIC SCATTERING BY A COMBINED SCATTERER

open access: yesMathematical Modelling and Analysis, 2015
This paper is concerned with the scattering problem of time-harmonic acoustic plane waves by a union of a crack and a penetrable inhomogeneous medium with compact support. The well-posedness of the direct problem is established by the variational method.
Jin, Jing, Guo, Jun, Cai, Mingjian
openaire   +3 more sources

Deep Variational Inverse Scattering

open access: yesCoRR, 2022
Inverse medium scattering solvers generally reconstruct a single solution without an associated measure of uncertainty. This is true both for the classical iterative solvers and for the emerging deep learning methods. But ill-posedness and noise can make this single estimate inaccurate or misleading.
AmirEhsan Khorashadizadeh   +4 more
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Inverse scattering on the half-line for energy-dependent Schrödinger equations

open access: yes, 2020
In this paper, we study the inverse scattering problem for energy-dependent Schrödinger equations on the half-line with energy-dependent boundary conditions at the origin.
Manko, Stepan, Hryniv, Rostyslav
core   +1 more source

Linear systems and determinantal random point fields. [PDF]

open access: yes, 2009
Tracy and Widom showed that fundamentally important kernels in random matrix theory arise from systems of differential equations with rational coefficient.
Blower, Gordon
core   +5 more sources

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini   +9 more
wiley   +1 more source

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