Results 41 to 50 of about 32,819 (260)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
HDR-LFNet: Inverse Tone Mapping using Fusion Network [PDF]
, 2022 To capture the real-world luminance values, High Dynamic Range (HDR) image processing has been developed. HDR images have a richer content than the widely-used Standard Dynamic Range (SDR) images, and are used in a number of situations, e.g.
Bouatouch, Kadi +5 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
IMPACT OF TONE MAPPING IN HIGH DYNAMIC RANGE IMAGE COMPRESSION [PDF]
, 2014 International audienceTone mapping or range reduction is often used in High Dynamic Range (HDR) visual signal compression to take advantage of the existing image/video coding architectures. Thus, it is important to study the impact of tone mapping on the
Pépion, Romuald +3 more
core +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Learning an Inverse Tone Mapping Network with a Generative Adversarial Regularizer [PDF]
2018 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2018 Transferring a low-dynamic-range (LDR) image to a high-dynamic-range (HDR) image, which is the so-called inverse tone mapping (iTM), is an important imaging technique to improve visual effects of imaging devices. In this paper, we propose a novel deep learning-based iTM method, which learns an inverse tone mapping network with a generative adversarial ...
Shiyu Ning +4 more
openaire +2 more sources
Rate-distortion optimization of a tone mapping with SDR quality constraint for backward-compatible high dynamic range compression [PDF]
, 2016 International audienceThis paper addresses the problem of designing a global tone mapping operator for rate-distortion optimized backward compatible compression of HDR images.
Guillemot, Christine +9 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source